In vivo evaluation of osseointegration ability of sintered bionic trabecular porous titanium alloy as artificial hip prosthesis
Hydroxyapatite (HA) coatings have been widely used for improving the bone-implant interface (BII) bonding of the artificial joint prostheses. However, the incidence of prosthetic revisions due to aseptic loosening remains high. Porous materials, including three-dimensional (3D) printing, can reduce...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.928216/full |
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| author | Xiaowei Bai Xiaowei Bai Xiaowei Bai Ji Li Zhidong Zhao Zhidong Zhao Qi Wang Qi Wang Ningyu Lv Ningyu Lv Yuxing Wang Huayi Gao Huayi Gao Zheng Guo Zheng Guo Zhongli Li Zhongli Li |
| author_facet | Xiaowei Bai Xiaowei Bai Xiaowei Bai Ji Li Zhidong Zhao Zhidong Zhao Qi Wang Qi Wang Ningyu Lv Ningyu Lv Yuxing Wang Huayi Gao Huayi Gao Zheng Guo Zheng Guo Zhongli Li Zhongli Li |
| author_sort | Xiaowei Bai |
| collection | DOAJ |
| description | Hydroxyapatite (HA) coatings have been widely used for improving the bone-implant interface (BII) bonding of the artificial joint prostheses. However, the incidence of prosthetic revisions due to aseptic loosening remains high. Porous materials, including three-dimensional (3D) printing, can reduce the elastic modulus and improve osseointegration at the BII. In our previous study, we identified a porous material with a sintered bionic trabecular structure with in vitro and in vivo bio-safety as well as in vivo mechanical safety. This study aimed to compare the difference in osseointegration ability of the different porous materials and HA-coated titanium alloy in the BII. We fabricated sintered bionic trabecular porous titanium acetabular cups, 3D-printed porous titanium acetabular cups, and HA-coated titanium alloy acetabular cups for producing a hip prosthesis suitable for beagle dogs. Subsequently, the imaging and histomorphological analysis of the three materials under mechanical loading in animals was performed (at months 1, 3, and 6). The results suggested that both sintered bionic porous titanium alloy and 3D-printed titanium alloy exhibited superior performances in promoting osseointegration at the BII than the HA-coated titanium alloy. In particular, the sintered bionic porous titanium alloy exhibited a favorable bone ingrowth performance at an early stage (month 1). A comparison of the two porous titanium alloys suggested that the sintered bionic porous titanium alloys exhibit superior bone in growth properties and osseointegration ability. Overall, our findings provide an experimental basis for the clinical application of sintered bionic trabecular porous titanium alloys. |
| first_indexed | 2024-04-12T21:21:03Z |
| format | Article |
| id | doaj.art-0c2e691d849648eb9af3521df1088348 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-12T21:21:03Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-0c2e691d849648eb9af3521df10883482022-12-22T03:16:18ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-09-011010.3389/fbioe.2022.928216928216In vivo evaluation of osseointegration ability of sintered bionic trabecular porous titanium alloy as artificial hip prosthesisXiaowei Bai0Xiaowei Bai1Xiaowei Bai2Ji Li3Zhidong Zhao4Zhidong Zhao5Qi Wang6Qi Wang7Ningyu Lv8Ningyu Lv9Yuxing Wang10Huayi Gao11Huayi Gao12Zheng Guo13Zheng Guo14Zhongli Li15Zhongli Li16Medical School of Chinese PLA, Beijing, ChinaDepartment of Orthopaedics, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaDepartment of Orthopaedics, The 987th Hospital of Logistics Support Force of Chinese PLA, Baoji, ChinaDepartment of Orthopaedics, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaMedical School of Chinese PLA, Beijing, ChinaDepartment of Orthopaedics, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaMedical School of Chinese PLA, Beijing, ChinaDepartment of Orthopaedics, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaMedical School of Chinese PLA, Beijing, ChinaDepartment of Orthopaedics, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaMedical School of Chinese PLA, Beijing, ChinaMedical School of Chinese PLA, Beijing, ChinaDepartment of Orthopaedics, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaMedical School of Chinese PLA, Beijing, ChinaDepartment of Orthopaedics, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaMedical School of Chinese PLA, Beijing, ChinaDepartment of Orthopaedics, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaHydroxyapatite (HA) coatings have been widely used for improving the bone-implant interface (BII) bonding of the artificial joint prostheses. However, the incidence of prosthetic revisions due to aseptic loosening remains high. Porous materials, including three-dimensional (3D) printing, can reduce the elastic modulus and improve osseointegration at the BII. In our previous study, we identified a porous material with a sintered bionic trabecular structure with in vitro and in vivo bio-safety as well as in vivo mechanical safety. This study aimed to compare the difference in osseointegration ability of the different porous materials and HA-coated titanium alloy in the BII. We fabricated sintered bionic trabecular porous titanium acetabular cups, 3D-printed porous titanium acetabular cups, and HA-coated titanium alloy acetabular cups for producing a hip prosthesis suitable for beagle dogs. Subsequently, the imaging and histomorphological analysis of the three materials under mechanical loading in animals was performed (at months 1, 3, and 6). The results suggested that both sintered bionic porous titanium alloy and 3D-printed titanium alloy exhibited superior performances in promoting osseointegration at the BII than the HA-coated titanium alloy. In particular, the sintered bionic porous titanium alloy exhibited a favorable bone ingrowth performance at an early stage (month 1). A comparison of the two porous titanium alloys suggested that the sintered bionic porous titanium alloys exhibit superior bone in growth properties and osseointegration ability. Overall, our findings provide an experimental basis for the clinical application of sintered bionic trabecular porous titanium alloys.https://www.frontiersin.org/articles/10.3389/fbioe.2022.928216/fullartificial jointaseptic looseningporous Ti6Al4Vbionic trabecular structureosseointergrationstress shielding |
| spellingShingle | Xiaowei Bai Xiaowei Bai Xiaowei Bai Ji Li Zhidong Zhao Zhidong Zhao Qi Wang Qi Wang Ningyu Lv Ningyu Lv Yuxing Wang Huayi Gao Huayi Gao Zheng Guo Zheng Guo Zhongli Li Zhongli Li In vivo evaluation of osseointegration ability of sintered bionic trabecular porous titanium alloy as artificial hip prosthesis Frontiers in Bioengineering and Biotechnology artificial joint aseptic loosening porous Ti6Al4V bionic trabecular structure osseointergration stress shielding |
| title | In vivo evaluation of osseointegration ability of sintered bionic trabecular porous titanium alloy as artificial hip prosthesis |
| title_full | In vivo evaluation of osseointegration ability of sintered bionic trabecular porous titanium alloy as artificial hip prosthesis |
| title_fullStr | In vivo evaluation of osseointegration ability of sintered bionic trabecular porous titanium alloy as artificial hip prosthesis |
| title_full_unstemmed | In vivo evaluation of osseointegration ability of sintered bionic trabecular porous titanium alloy as artificial hip prosthesis |
| title_short | In vivo evaluation of osseointegration ability of sintered bionic trabecular porous titanium alloy as artificial hip prosthesis |
| title_sort | in vivo evaluation of osseointegration ability of sintered bionic trabecular porous titanium alloy as artificial hip prosthesis |
| topic | artificial joint aseptic loosening porous Ti6Al4V bionic trabecular structure osseointergration stress shielding |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.928216/full |
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