Mycobacterium leprae and Mycobacterium lepromatosis in small mammals in Midwest Brazil
Leprosy is a chronic infectious disease caused by the bacilli Mycobacterium leprae and Mycobacterium lepromatosis. In addition to humans, animals such as nine-banded armadillos and red squirrels are species naturally infected. The objective of this study was to investigate the presence of M. leprae...
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| Formaat: | Artikel |
| Taal: | English |
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Elsevier
2024-09-01
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| Reeks: | Brazilian Journal of Infectious Diseases |
| Onderwerpen: | |
| Online toegang: | http://www.sciencedirect.com/science/article/pii/S1413867024001570 |
| _version_ | 1827049797496864768 |
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| author | Beatriz Silva Nogueira Maerle Oliveira Maia Ravena Fernanda Braga de Mendonça Luciano Nakazato Valéria Dutra |
| author_facet | Beatriz Silva Nogueira Maerle Oliveira Maia Ravena Fernanda Braga de Mendonça Luciano Nakazato Valéria Dutra |
| author_sort | Beatriz Silva Nogueira |
| collection | DOAJ |
| description | Leprosy is a chronic infectious disease caused by the bacilli Mycobacterium leprae and Mycobacterium lepromatosis. In addition to humans, animals such as nine-banded armadillos and red squirrels are species naturally infected. The objective of this study was to investigate the presence of M. leprae and M. lepromatosis in non-volant small mammals of the order Didelphimorphia and Rodentia through Polymerase Chain Reaction (PCR) assay. During 2015 and 2018, field expeditions were carried out in three municipalities, covering biotic elements of the Amazon and Cerrado biomes, in the Mato Grosso State, Midwest of Brazil. A specific primer for repetitive sequences of the genomic DNA of M. leprae and M. lepromatosis targeting the RLEP and RLPM gene, respectively, was used to screen for these agents. The molecular detection of M. leprae DNA in the samples was 13.8%. M. lepromatosis was not detected. The present study reports a description of M. leprae in small non-volant mammals in Brazil. |
| first_indexed | 2025-02-18T15:50:06Z |
| format | Article |
| id | doaj.art-0c2f1518a0144e848b51f606469e4bbd |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2025-02-18T15:50:06Z |
| publishDate | 2024-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-0c2f1518a0144e848b51f606469e4bbd2024-10-25T04:23:02ZengElsevierBrazilian Journal of Infectious Diseases1413-86702024-09-01285103874Mycobacterium leprae and Mycobacterium lepromatosis in small mammals in Midwest BrazilBeatriz Silva Nogueira0Maerle Oliveira Maia1Ravena Fernanda Braga de Mendonça2Luciano Nakazato3Valéria Dutra4Universidade Federal de Mato Grosso, Faculdade de Medicina Veterinária, Departamento de Microbiologia e Biologia Molecular, Cuiabá, MT, Brazil; Corresponding author.Universidade Federal de Mato Grosso, Faculdade de Medicina Veterinária, Departamento de Microbiologia e Biologia Molecular, Cuiabá, MT, BrazilUniversidade Federal de Mato Grosso, Instituto de Biociências, Departamento de Biologia e Zoologia, Cuiabá, MT, BrazilUniversidade Federal de Mato Grosso, Faculdade de Medicina Veterinária, Departamento de Microbiologia e Biologia Molecular, Cuiabá, MT, BrazilUniversidade Federal de Mato Grosso, Faculdade de Medicina Veterinária, Departamento de Microbiologia e Biologia Molecular, Cuiabá, MT, BrazilLeprosy is a chronic infectious disease caused by the bacilli Mycobacterium leprae and Mycobacterium lepromatosis. In addition to humans, animals such as nine-banded armadillos and red squirrels are species naturally infected. The objective of this study was to investigate the presence of M. leprae and M. lepromatosis in non-volant small mammals of the order Didelphimorphia and Rodentia through Polymerase Chain Reaction (PCR) assay. During 2015 and 2018, field expeditions were carried out in three municipalities, covering biotic elements of the Amazon and Cerrado biomes, in the Mato Grosso State, Midwest of Brazil. A specific primer for repetitive sequences of the genomic DNA of M. leprae and M. lepromatosis targeting the RLEP and RLPM gene, respectively, was used to screen for these agents. The molecular detection of M. leprae DNA in the samples was 13.8%. M. lepromatosis was not detected. The present study reports a description of M. leprae in small non-volant mammals in Brazil.http://www.sciencedirect.com/science/article/pii/S1413867024001570RLEPRLPMAmazoniaCerrado |
| spellingShingle | Beatriz Silva Nogueira Maerle Oliveira Maia Ravena Fernanda Braga de Mendonça Luciano Nakazato Valéria Dutra Mycobacterium leprae and Mycobacterium lepromatosis in small mammals in Midwest Brazil Brazilian Journal of Infectious Diseases RLEP RLPM Amazonia Cerrado |
| title | Mycobacterium leprae and Mycobacterium lepromatosis in small mammals in Midwest Brazil |
| title_full | Mycobacterium leprae and Mycobacterium lepromatosis in small mammals in Midwest Brazil |
| title_fullStr | Mycobacterium leprae and Mycobacterium lepromatosis in small mammals in Midwest Brazil |
| title_full_unstemmed | Mycobacterium leprae and Mycobacterium lepromatosis in small mammals in Midwest Brazil |
| title_short | Mycobacterium leprae and Mycobacterium lepromatosis in small mammals in Midwest Brazil |
| title_sort | mycobacterium leprae and mycobacterium lepromatosis in small mammals in midwest brazil |
| topic | RLEP RLPM Amazonia Cerrado |
| url | http://www.sciencedirect.com/science/article/pii/S1413867024001570 |
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