Developments in Blood-Brain Barrier Penetrance and Drug Repurposing for Improved Treatment of Glioblastoma

Developments in Blood-Brain Barrier Penetrance and Drug Repurposing for Improved Treatment of Glioblastoma

Glioblastoma (GBM) is one of the most common, deadly, and difficult-to-treat adult brain tumors. Surgical removal of the tumor, followed by radiotherapy (RT) and temozolomide (TMZ) administration, is the current treatment modality, but this regimen only modestly improves overall patient survival. In...

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Bibliographic Details
Main Authors: Bryan G. Harder, Mylan R. Blomquist, Junwen Wang, Anthony J. Kim, Graeme F. Woodworth, Jeffrey A. Winkles, Joseph C. Loftus, Nhan L. Tran
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Oncology
Subjects:
GBM
glioblastoma
Blood-brain barrier
repurposed drugs
recurrent GBM
pharmacotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00462/full

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