Design, Synthesis, and Antitumor Activity of a Series of Novel 4-(Aromatic Sulfonyl)-1-oxa-4-azaspiro[4.5]deca-6,9-dien-8-ones

Design, Synthesis, and Antitumor Activity of a Series of Novel 4-(Aromatic Sulfonyl)-1-oxa-4-azaspiro[4.5]deca-6,9-dien-8-ones

Many sulfonamides show anticancer activity. Based on benzenesulfonylazaspirodienone (HL-X9) identified in our previous work, we optimized the lead compound for better efficacy, thereby synthesizing a series of novel 4-(aromatic sulfonyl)-1-oxa-4-azaspiro[4.5]deca-6,9-dien-8-one derivatives through a...

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Bibliographic Details
Main Authors: Naiguo Xing, Chen Chen, Qiu Zhong, Shilong Zheng, Guangdi Wang, Ling He
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Molecules
Subjects:
sulfonylazaspirodienone
metal-catalyzed cascade cyclization
antitumor activity
Online Access:https://www.mdpi.com/1420-3049/25/22/5459

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https://www.mdpi.com/1420-3049/25/22/5459

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