Current tuberculosis incidence among children; medicines for prevention and diagnosis of TB
The article analyses main epidemiological parameters of tuberculosis (TB) in children and adolescents in Russia. It was demonstrated that the incidence rate in this population, though decreasing, is still high. The disease incidence in children and adolescents arising from contacts with people with...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»
2018-02-01
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| Series: | Биопрепараты: Профилактика, диагностика, лечение |
| Subjects: | |
| Online Access: | https://www.biopreparations.ru/jour/article/view/96 |
| _version_ | 1797244535446700032 |
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| author | V. A. Aksenova D. T. Levi N. V. Aleksandrova D. A. Kudlay |
| author_facet | V. A. Aksenova D. T. Levi N. V. Aleksandrova D. A. Kudlay |
| author_sort | V. A. Aksenova |
| collection | DOAJ |
| description | The article analyses main epidemiological parameters of tuberculosis (TB) in children and adolescents in Russia. It was demonstrated that the incidence rate in this population, though decreasing, is still high. The disease incidence in children and adolescents arising from contacts with people with active TB is 30 and 25 times higher than the overall incidence rate in children and adolescents in Russia, respectively. Analysis of TB lesions in a major proportion of children and adolescents shows multi-drug resistant strains of Mycobacteria tuberculosis (MTB), and this calls for revision of approaches to preventive actions for this population. The tuberculine Mantoux test is of limited value when it comes to diagnosing TB in adolescents. Screening in adolescents and children older than 7 years is performed using Diaskintest® containing two MBT-specific antigens. Specific TB prevention for newborns is performed by vaccination with BCG and BCG-M living vaccines. The product was modified by a 30 % reduction of the number of BCG living cells per 1 mg of vaccine in order to reduce postvaccinal complications largely associated with residual virulence of the BCG substrain. Since 2012 BCG vaccine lots have been standardized to contain from 500 thousand to 1 million viable BCG cells per BCG vaccine dose and from 375 thousand to 575 thousand viable BCG cells per BCG-M vaccine dose. |
| first_indexed | 2024-03-08T21:43:42Z |
| format | Article |
| id | doaj.art-0c31eb1b323b4778b1b5cbcbf5d5f3c9 |
| institution | Directory Open Access Journal |
| issn | 2221-996X 2619-1156 |
| language | Russian |
| last_indexed | 2024-04-24T19:12:33Z |
| publishDate | 2018-02-01 |
| publisher | Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» |
| record_format | Article |
| series | Биопрепараты: Профилактика, диагностика, лечение |
| spelling | doaj.art-0c31eb1b323b4778b1b5cbcbf5d5f3c92024-03-26T09:10:52ZrusMinistry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»Биопрепараты: Профилактика, диагностика, лечение2221-996X2619-11562018-02-0117314515196Current tuberculosis incidence among children; medicines for prevention and diagnosis of TBV. A. Aksenova0D. T. Levi1N. V. Aleksandrova2D. A. Kudlay3I. M. Sechenov First Moscow State Medical University, Research Institute of PhthisiopulmonologyScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsProfessional Development InstitutionThe article analyses main epidemiological parameters of tuberculosis (TB) in children and adolescents in Russia. It was demonstrated that the incidence rate in this population, though decreasing, is still high. The disease incidence in children and adolescents arising from contacts with people with active TB is 30 and 25 times higher than the overall incidence rate in children and adolescents in Russia, respectively. Analysis of TB lesions in a major proportion of children and adolescents shows multi-drug resistant strains of Mycobacteria tuberculosis (MTB), and this calls for revision of approaches to preventive actions for this population. The tuberculine Mantoux test is of limited value when it comes to diagnosing TB in adolescents. Screening in adolescents and children older than 7 years is performed using Diaskintest® containing two MBT-specific antigens. Specific TB prevention for newborns is performed by vaccination with BCG and BCG-M living vaccines. The product was modified by a 30 % reduction of the number of BCG living cells per 1 mg of vaccine in order to reduce postvaccinal complications largely associated with residual virulence of the BCG substrain. Since 2012 BCG vaccine lots have been standardized to contain from 500 thousand to 1 million viable BCG cells per BCG vaccine dose and from 375 thousand to 575 thousand viable BCG cells per BCG-M vaccine dose.https://www.biopreparations.ru/jour/article/view/96заболеваемость туберкулезоммикобактерии туберкулеза (мбт)скрининговые иммунологические пробы (манту и диаскинтест)вакцина бцжосложнения вакцинацииtuberculosis incidencemycobacteria tuberculosis (mtb)immunological screening tests (mantoux and diaskintest)bcg vaccinepostvaccinal complications |
| spellingShingle | V. A. Aksenova D. T. Levi N. V. Aleksandrova D. A. Kudlay Current tuberculosis incidence among children; medicines for prevention and diagnosis of TB Биопрепараты: Профилактика, диагностика, лечение заболеваемость туберкулезом микобактерии туберкулеза (мбт) скрининговые иммунологические пробы (манту и диаскинтест) вакцина бцж осложнения вакцинации tuberculosis incidence mycobacteria tuberculosis (mtb) immunological screening tests (mantoux and diaskintest) bcg vaccine postvaccinal complications |
| title | Current tuberculosis incidence among children; medicines for prevention and diagnosis of TB |
| title_full | Current tuberculosis incidence among children; medicines for prevention and diagnosis of TB |
| title_fullStr | Current tuberculosis incidence among children; medicines for prevention and diagnosis of TB |
| title_full_unstemmed | Current tuberculosis incidence among children; medicines for prevention and diagnosis of TB |
| title_short | Current tuberculosis incidence among children; medicines for prevention and diagnosis of TB |
| title_sort | current tuberculosis incidence among children medicines for prevention and diagnosis of tb |
| topic | заболеваемость туберкулезом микобактерии туберкулеза (мбт) скрининговые иммунологические пробы (манту и диаскинтест) вакцина бцж осложнения вакцинации tuberculosis incidence mycobacteria tuberculosis (mtb) immunological screening tests (mantoux and diaskintest) bcg vaccine postvaccinal complications |
| url | https://www.biopreparations.ru/jour/article/view/96 |
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