CCL2: a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir

CCL2: a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir

ABSTRACT HIV infects long-lived CD4 memory T cells, establishing a latent viral reservoir that necessitates lifelong antiretroviral therapy (ART). How this reservoir is formed so quickly after infection remains unclear. We now show the innate inflammatory response to HIV infection results in CCL2 ch...

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Bibliographic Details
Main Authors: Thomas A. Packard, Roland Schwarzer, Eytan Herzig, Deepashri Rao, Xiaoyu Luo, Johanne H. Egedal, Feng Hsiao, Marek Widera, Judd F. Hultquist, Zachary W. Grimmett, Ronald J. Messer, Nevan J. Krogan, Steven G. Deeks, Nadia R. Roan, Ulf Dittmer, Kim J. Hasenkrug, Warner C. Greene
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:mBio
Subjects:
CCL2
CRISPR
CyTOF
human immunodeficiency virus
latency
reservoir
Online Access:https://journals.asm.org/doi/10.1128/mbio.01891-22

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