Pharmacogenomics of Hypersensitivity to Non-steroidal Anti-inflammatory Drugs
Non-steroidal anti-inflammatory drugs (NSAIDs) are extensively prescribed in daily clinical practice. NSAIDs are the main cause of drug hypersensitivity reactions all over the world. The inhibition of cyclooxygenase enzymes by NSAIDs can perpetuate arachidonic acid metabolism, shunting to the 5-lipo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2021.647257/full |
| _version_ | 1829502223368847360 |
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| author | Hoang Kim Tu Trinh Le Duy Pham Kieu Minh Le Hae-Sim Park |
| author_facet | Hoang Kim Tu Trinh Le Duy Pham Kieu Minh Le Hae-Sim Park |
| author_sort | Hoang Kim Tu Trinh |
| collection | DOAJ |
| description | Non-steroidal anti-inflammatory drugs (NSAIDs) are extensively prescribed in daily clinical practice. NSAIDs are the main cause of drug hypersensitivity reactions all over the world. The inhibition of cyclooxygenase enzymes by NSAIDs can perpetuate arachidonic acid metabolism, shunting to the 5-lipoxygenase pathway and its downstream inflammatory process. Clinical phenotypes of NSAID hypersensitivity are diverse and can be classified into cross-reactive or selective responses. Efforts have been made to understand pathogenic mechanisms, in which, genetic and epigenetic backgrounds are implicated in various processes of NSAID-induced hypersensitivity reactions. Although there were some similarities among patients, several genetic polymorphisms are distinct in those exhibiting respiratory or cutaneous symptoms. Moreover, the expression levels, as well as the methylation status of genes related to immune responses were demonstrated to be involved in NSAID-induced hypersensitivity reactions. There is still a lack of data on delayed type reactions. Further studies with a larger sample size, which integrate different genetic pathways, can help overcome current limitations of gen etic/epigenetic studies, and provide valuable information on NSAID hypersensitivity reactions. |
| first_indexed | 2024-12-16T09:34:07Z |
| format | Article |
| id | doaj.art-0c352b81eac44a71910ef5ec8c91bfe5 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-16T09:34:07Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-0c352b81eac44a71910ef5ec8c91bfe52022-12-21T22:36:27ZengFrontiers Media S.A.Frontiers in Genetics1664-80212021-06-011210.3389/fgene.2021.647257647257Pharmacogenomics of Hypersensitivity to Non-steroidal Anti-inflammatory DrugsHoang Kim Tu Trinh0Le Duy Pham1Kieu Minh Le2Hae-Sim Park3Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, VietnamFaculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, VietnamCenter for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, VietnamDepartment of Allergy and Clinical Immunology, Ajou University Medical Center, Suwon, South KoreaNon-steroidal anti-inflammatory drugs (NSAIDs) are extensively prescribed in daily clinical practice. NSAIDs are the main cause of drug hypersensitivity reactions all over the world. The inhibition of cyclooxygenase enzymes by NSAIDs can perpetuate arachidonic acid metabolism, shunting to the 5-lipoxygenase pathway and its downstream inflammatory process. Clinical phenotypes of NSAID hypersensitivity are diverse and can be classified into cross-reactive or selective responses. Efforts have been made to understand pathogenic mechanisms, in which, genetic and epigenetic backgrounds are implicated in various processes of NSAID-induced hypersensitivity reactions. Although there were some similarities among patients, several genetic polymorphisms are distinct in those exhibiting respiratory or cutaneous symptoms. Moreover, the expression levels, as well as the methylation status of genes related to immune responses were demonstrated to be involved in NSAID-induced hypersensitivity reactions. There is still a lack of data on delayed type reactions. Further studies with a larger sample size, which integrate different genetic pathways, can help overcome current limitations of gen etic/epigenetic studies, and provide valuable information on NSAID hypersensitivity reactions.https://www.frontiersin.org/articles/10.3389/fgene.2021.647257/fullasthmaurticariaepigeneticnon-steroidal anti-inflammatory drughypersensitivitygenetic polymorphism |
| spellingShingle | Hoang Kim Tu Trinh Le Duy Pham Kieu Minh Le Hae-Sim Park Pharmacogenomics of Hypersensitivity to Non-steroidal Anti-inflammatory Drugs Frontiers in Genetics asthma urticaria epigenetic non-steroidal anti-inflammatory drug hypersensitivity genetic polymorphism |
| title | Pharmacogenomics of Hypersensitivity to Non-steroidal Anti-inflammatory Drugs |
| title_full | Pharmacogenomics of Hypersensitivity to Non-steroidal Anti-inflammatory Drugs |
| title_fullStr | Pharmacogenomics of Hypersensitivity to Non-steroidal Anti-inflammatory Drugs |
| title_full_unstemmed | Pharmacogenomics of Hypersensitivity to Non-steroidal Anti-inflammatory Drugs |
| title_short | Pharmacogenomics of Hypersensitivity to Non-steroidal Anti-inflammatory Drugs |
| title_sort | pharmacogenomics of hypersensitivity to non steroidal anti inflammatory drugs |
| topic | asthma urticaria epigenetic non-steroidal anti-inflammatory drug hypersensitivity genetic polymorphism |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2021.647257/full |
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