Maxillary Sinus Augmentation Using Autologous Platelet Concentrates (Platelet-Rich Plasma, Platelet-Rich Fibrin, and Concentrated Growth Factor) Combined with Bone Graft: A Systematic Review
Background: The current review aims to provide an overview of the most recent research on the potentials of concentrated growth factors used in the maxillary sinus lift technique. Materials and methods: “PRP”, “PRF”, “L-PRF”, “CGF”, “oral surgery”, “sticky bone”, “sinus lift” were the search terms u...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/12/13/1797 |
| _version_ | 1797591878146719744 |
|---|---|
| author | Giuseppina Malcangi Assunta Patano Giulia Palmieri Chiara Di Pede Giulia Latini Alessio Danilo Inchingolo Denisa Hazballa Elisabetta de Ruvo Grazia Garofoli Francesco Inchingolo Gianna Dipalma Elio Minetti Angelo Michele Inchingolo |
| author_facet | Giuseppina Malcangi Assunta Patano Giulia Palmieri Chiara Di Pede Giulia Latini Alessio Danilo Inchingolo Denisa Hazballa Elisabetta de Ruvo Grazia Garofoli Francesco Inchingolo Gianna Dipalma Elio Minetti Angelo Michele Inchingolo |
| author_sort | Giuseppina Malcangi |
| collection | DOAJ |
| description | Background: The current review aims to provide an overview of the most recent research on the potentials of concentrated growth factors used in the maxillary sinus lift technique. Materials and methods: “PRP”, “PRF”, “L-PRF”, “CGF”, “oral surgery”, “sticky bone”, “sinus lift” were the search terms utilized in the databases Scopus, Web of Science, and Pubmed, with the Boolean operator “AND” and “OR”. Results: Of these 1534 studies, 22 publications were included for this review. Discussion: The autologous growth factors released from platelet concentrates can help to promote bone remodeling and cell proliferation, and the application of platelet concentrates appears to reduce the amount of autologous bone required during regenerative surgery. Many authors agree that growth factors considerably enhance early vascularization in bone grafts and have a significantly positive pro-angiogenic influence in vivo when combined with alloplastic and xenogeneic materials, reducing inflammation and postoperative pain and stimulating the regeneration of injured tissues and accelerating their healing. Conclusions: Even if further studies are still needed, the use of autologous platelet concentrates can improve clinical results where a large elevation of the sinus is needed by improving bone height, thickness and vascularization of surgical sites, and post-operative healing. |
| first_indexed | 2024-03-11T01:44:47Z |
| format | Article |
| id | doaj.art-0c36033afe8b40a2a2d1adc361fa7b57 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T01:44:47Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-0c36033afe8b40a2a2d1adc361fa7b572023-11-18T16:20:12ZengMDPI AGCells2073-44092023-07-011213179710.3390/cells12131797Maxillary Sinus Augmentation Using Autologous Platelet Concentrates (Platelet-Rich Plasma, Platelet-Rich Fibrin, and Concentrated Growth Factor) Combined with Bone Graft: A Systematic ReviewGiuseppina Malcangi0Assunta Patano1Giulia Palmieri2Chiara Di Pede3Giulia Latini4Alessio Danilo Inchingolo5Denisa Hazballa6Elisabetta de Ruvo7Grazia Garofoli8Francesco Inchingolo9Gianna Dipalma10Elio Minetti11Angelo Michele Inchingolo12Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyInterdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyInterdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyInterdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyInterdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyInterdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyInterdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyInterdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyInterdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyInterdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyInterdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Biomedical, Surgical, Dental Science, University of Milan, 20161 Milan, ItalyInterdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyBackground: The current review aims to provide an overview of the most recent research on the potentials of concentrated growth factors used in the maxillary sinus lift technique. Materials and methods: “PRP”, “PRF”, “L-PRF”, “CGF”, “oral surgery”, “sticky bone”, “sinus lift” were the search terms utilized in the databases Scopus, Web of Science, and Pubmed, with the Boolean operator “AND” and “OR”. Results: Of these 1534 studies, 22 publications were included for this review. Discussion: The autologous growth factors released from platelet concentrates can help to promote bone remodeling and cell proliferation, and the application of platelet concentrates appears to reduce the amount of autologous bone required during regenerative surgery. Many authors agree that growth factors considerably enhance early vascularization in bone grafts and have a significantly positive pro-angiogenic influence in vivo when combined with alloplastic and xenogeneic materials, reducing inflammation and postoperative pain and stimulating the regeneration of injured tissues and accelerating their healing. Conclusions: Even if further studies are still needed, the use of autologous platelet concentrates can improve clinical results where a large elevation of the sinus is needed by improving bone height, thickness and vascularization of surgical sites, and post-operative healing.https://www.mdpi.com/2073-4409/12/13/1797PRPPRFCGFSinus Lift (S.L.)oral surgerygrowth factor |
| spellingShingle | Giuseppina Malcangi Assunta Patano Giulia Palmieri Chiara Di Pede Giulia Latini Alessio Danilo Inchingolo Denisa Hazballa Elisabetta de Ruvo Grazia Garofoli Francesco Inchingolo Gianna Dipalma Elio Minetti Angelo Michele Inchingolo Maxillary Sinus Augmentation Using Autologous Platelet Concentrates (Platelet-Rich Plasma, Platelet-Rich Fibrin, and Concentrated Growth Factor) Combined with Bone Graft: A Systematic Review Cells PRP PRF CGF Sinus Lift (S.L.) oral surgery growth factor |
| title | Maxillary Sinus Augmentation Using Autologous Platelet Concentrates (Platelet-Rich Plasma, Platelet-Rich Fibrin, and Concentrated Growth Factor) Combined with Bone Graft: A Systematic Review |
| title_full | Maxillary Sinus Augmentation Using Autologous Platelet Concentrates (Platelet-Rich Plasma, Platelet-Rich Fibrin, and Concentrated Growth Factor) Combined with Bone Graft: A Systematic Review |
| title_fullStr | Maxillary Sinus Augmentation Using Autologous Platelet Concentrates (Platelet-Rich Plasma, Platelet-Rich Fibrin, and Concentrated Growth Factor) Combined with Bone Graft: A Systematic Review |
| title_full_unstemmed | Maxillary Sinus Augmentation Using Autologous Platelet Concentrates (Platelet-Rich Plasma, Platelet-Rich Fibrin, and Concentrated Growth Factor) Combined with Bone Graft: A Systematic Review |
| title_short | Maxillary Sinus Augmentation Using Autologous Platelet Concentrates (Platelet-Rich Plasma, Platelet-Rich Fibrin, and Concentrated Growth Factor) Combined with Bone Graft: A Systematic Review |
| title_sort | maxillary sinus augmentation using autologous platelet concentrates platelet rich plasma platelet rich fibrin and concentrated growth factor combined with bone graft a systematic review |
| topic | PRP PRF CGF Sinus Lift (S.L.) oral surgery growth factor |
| url | https://www.mdpi.com/2073-4409/12/13/1797 |
| work_keys_str_mv | AT giuseppinamalcangi maxillarysinusaugmentationusingautologousplateletconcentratesplateletrichplasmaplateletrichfibrinandconcentratedgrowthfactorcombinedwithbonegraftasystematicreview AT assuntapatano maxillarysinusaugmentationusingautologousplateletconcentratesplateletrichplasmaplateletrichfibrinandconcentratedgrowthfactorcombinedwithbonegraftasystematicreview AT giuliapalmieri maxillarysinusaugmentationusingautologousplateletconcentratesplateletrichplasmaplateletrichfibrinandconcentratedgrowthfactorcombinedwithbonegraftasystematicreview AT chiaradipede maxillarysinusaugmentationusingautologousplateletconcentratesplateletrichplasmaplateletrichfibrinandconcentratedgrowthfactorcombinedwithbonegraftasystematicreview AT giulialatini maxillarysinusaugmentationusingautologousplateletconcentratesplateletrichplasmaplateletrichfibrinandconcentratedgrowthfactorcombinedwithbonegraftasystematicreview AT alessiodaniloinchingolo maxillarysinusaugmentationusingautologousplateletconcentratesplateletrichplasmaplateletrichfibrinandconcentratedgrowthfactorcombinedwithbonegraftasystematicreview AT denisahazballa maxillarysinusaugmentationusingautologousplateletconcentratesplateletrichplasmaplateletrichfibrinandconcentratedgrowthfactorcombinedwithbonegraftasystematicreview AT elisabettaderuvo maxillarysinusaugmentationusingautologousplateletconcentratesplateletrichplasmaplateletrichfibrinandconcentratedgrowthfactorcombinedwithbonegraftasystematicreview AT graziagarofoli maxillarysinusaugmentationusingautologousplateletconcentratesplateletrichplasmaplateletrichfibrinandconcentratedgrowthfactorcombinedwithbonegraftasystematicreview AT francescoinchingolo maxillarysinusaugmentationusingautologousplateletconcentratesplateletrichplasmaplateletrichfibrinandconcentratedgrowthfactorcombinedwithbonegraftasystematicreview AT giannadipalma maxillarysinusaugmentationusingautologousplateletconcentratesplateletrichplasmaplateletrichfibrinandconcentratedgrowthfactorcombinedwithbonegraftasystematicreview AT eliominetti maxillarysinusaugmentationusingautologousplateletconcentratesplateletrichplasmaplateletrichfibrinandconcentratedgrowthfactorcombinedwithbonegraftasystematicreview AT angelomicheleinchingolo maxillarysinusaugmentationusingautologousplateletconcentratesplateletrichplasmaplateletrichfibrinandconcentratedgrowthfactorcombinedwithbonegraftasystematicreview |