Lorentzian-Corrected Apparent Exchange-Dependent Relaxation (LAREX) Ω-Plot Analysis—An Adaptation for qCEST in a Multi-Pool System: Comprehensive In Silico, In Situ, and In Vivo Studies

Lorentzian-Corrected Apparent Exchange-Dependent Relaxation (LAREX) Ω-Plot Analysis—An Adaptation for qCEST in a Multi-Pool System: Comprehensive In Silico, In Situ, and In Vivo Studies

Based on in silico, in situ, and in vivo studies, this study aims to develop a new method for the quantitative chemical exchange saturation transfer (qCEST) technique considering multi-pool systems. To this end, we extended the state-of-the-art apparent exchange-dependent relaxation (AREX) method wi...

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Bibliographic Details
Main Authors: Karl Ludger Radke, Lena Marie Wilms, Miriam Frenken, Julia Stabinska, Marek Knet, Benedikt Kamp, Thomas Andreas Thiel, Timm Joachim Filler, Sven Nebelung, Gerald Antoch, Daniel Benjamin Abrar, Hans-Jörg Wittsack, Anja Müller-Lutz
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
magnetic resonance imaging
molecular imaging
CEST
qCEST
in situ
in vivo
Online Access:https://www.mdpi.com/1422-0067/23/13/6920

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