Case Report: Cannabidiol-Induced Skin Rash: A Case Series and Key Recommendations
Cannabidiol (CBD) is a non-psychotomimetic constituent of the Cannabis plant, with potential therapeutic properties for many physical and neuropsychiatric conditions. Isolated CBD has been suggested to have favorable safety and tolerability. Although CBD-related rash is described, few case reports a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.881617/full |
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| author | José Diogo S. Souza Maíra Fassoni-Ribeiro Rayssa Miranda Batista Juliana Mayumi Ushirohira Antonio W. Zuardi Antonio W. Zuardi Francisco S. Guimarães Francisco S. Guimarães Alline C. Campos Flávia de Lima Osório Flávia de Lima Osório Daniel Elias Cacilda S. Souza AndRea A. Fassoni Jaime E. C. Hallak Jaime E. C. Hallak José Alexandre S. Crippa José Alexandre S. Crippa |
| author_facet | José Diogo S. Souza Maíra Fassoni-Ribeiro Rayssa Miranda Batista Juliana Mayumi Ushirohira Antonio W. Zuardi Antonio W. Zuardi Francisco S. Guimarães Francisco S. Guimarães Alline C. Campos Flávia de Lima Osório Flávia de Lima Osório Daniel Elias Cacilda S. Souza AndRea A. Fassoni Jaime E. C. Hallak Jaime E. C. Hallak José Alexandre S. Crippa José Alexandre S. Crippa |
| author_sort | José Diogo S. Souza |
| collection | DOAJ |
| description | Cannabidiol (CBD) is a non-psychotomimetic constituent of the Cannabis plant, with potential therapeutic properties for many physical and neuropsychiatric conditions. Isolated CBD has been suggested to have favorable safety and tolerability. Although CBD-related rash is described, few case reports are well documented in the literature, and usually, CBD was used concomitantly with other medications. Thus, we report four women who presented a skin rash after ongoing CBD use. Other causes of these skin rashes were ruled out after conducting an extensive viral and serological detection panel, and three patients had their lesions biopsied. Two patients were re-exposed to the vehicle (MCT) without developing a new skin rash. Therefore, clinicians must be aware of this potential adverse effect of CBD use. |
| first_indexed | 2024-12-12T16:28:47Z |
| format | Article |
| id | doaj.art-0c39068f04cb40de88ef3f0832644c05 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-12T16:28:47Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-0c39068f04cb40de88ef3f0832644c052022-12-22T00:18:49ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-05-011310.3389/fphar.2022.881617881617Case Report: Cannabidiol-Induced Skin Rash: A Case Series and Key RecommendationsJosé Diogo S. Souza0Maíra Fassoni-Ribeiro1Rayssa Miranda Batista2Juliana Mayumi Ushirohira3Antonio W. Zuardi4Antonio W. Zuardi5Francisco S. Guimarães6Francisco S. Guimarães7Alline C. Campos8Flávia de Lima Osório9Flávia de Lima Osório10Daniel Elias11Cacilda S. Souza12AndRea A. Fassoni13Jaime E. C. Hallak14Jaime E. C. Hallak15José Alexandre S. Crippa16José Alexandre S. Crippa17Department of Neurosciences and Behavior, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilDepartment of Dermatology, São Paulo Federal University, São Paulo, BrazilDivision of Dermatology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilDepartment of Neurosciences and Behavior, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilDepartment of Neurosciences and Behavior, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilNational Institute of Science and Technology—Translational Medicine, Ribeirão Preto, BrazilNational Institute of Science and Technology—Translational Medicine, Ribeirão Preto, BrazilDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilDepartment of Neurosciences and Behavior, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilNational Institute of Science and Technology—Translational Medicine, Ribeirão Preto, BrazilDivision of Dermatology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilDivision of Dermatology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilAnatomed Laboratory, Bauru, BrazilDepartment of Neurosciences and Behavior, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilNational Institute of Science and Technology—Translational Medicine, Ribeirão Preto, BrazilDepartment of Neurosciences and Behavior, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilNational Institute of Science and Technology—Translational Medicine, Ribeirão Preto, BrazilCannabidiol (CBD) is a non-psychotomimetic constituent of the Cannabis plant, with potential therapeutic properties for many physical and neuropsychiatric conditions. Isolated CBD has been suggested to have favorable safety and tolerability. Although CBD-related rash is described, few case reports are well documented in the literature, and usually, CBD was used concomitantly with other medications. Thus, we report four women who presented a skin rash after ongoing CBD use. Other causes of these skin rashes were ruled out after conducting an extensive viral and serological detection panel, and three patients had their lesions biopsied. Two patients were re-exposed to the vehicle (MCT) without developing a new skin rash. Therefore, clinicians must be aware of this potential adverse effect of CBD use.https://www.frontiersin.org/articles/10.3389/fphar.2022.881617/fullcannabidioldrug interactionside effectsskin rashcase reportcase series |
| spellingShingle | José Diogo S. Souza Maíra Fassoni-Ribeiro Rayssa Miranda Batista Juliana Mayumi Ushirohira Antonio W. Zuardi Antonio W. Zuardi Francisco S. Guimarães Francisco S. Guimarães Alline C. Campos Flávia de Lima Osório Flávia de Lima Osório Daniel Elias Cacilda S. Souza AndRea A. Fassoni Jaime E. C. Hallak Jaime E. C. Hallak José Alexandre S. Crippa José Alexandre S. Crippa Case Report: Cannabidiol-Induced Skin Rash: A Case Series and Key Recommendations Frontiers in Pharmacology cannabidiol drug interaction side effects skin rash case report case series |
| title | Case Report: Cannabidiol-Induced Skin Rash: A Case Series and Key Recommendations |
| title_full | Case Report: Cannabidiol-Induced Skin Rash: A Case Series and Key Recommendations |
| title_fullStr | Case Report: Cannabidiol-Induced Skin Rash: A Case Series and Key Recommendations |
| title_full_unstemmed | Case Report: Cannabidiol-Induced Skin Rash: A Case Series and Key Recommendations |
| title_short | Case Report: Cannabidiol-Induced Skin Rash: A Case Series and Key Recommendations |
| title_sort | case report cannabidiol induced skin rash a case series and key recommendations |
| topic | cannabidiol drug interaction side effects skin rash case report case series |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.881617/full |
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