Amino acid residues in five separate HLA genes can explain most of the known associations between the MHC and primary biliary cholangitis.

Amino acid residues in five separate HLA genes can explain most of the known associations between the MHC and primary biliary cholangitis.

Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disease characterised by progressive destruction of intrahepatic bile ducts. The strongest genetic association is with HLA-DQA1*04:01, but at least three additional independent HLA haplotypes contribute to susceptibility. We used dense...

ver descrição completa

Detalhes bibliográficos
Principais autores: Rebecca Darlay, Kristin L Ayers, George F Mells, Lynsey S Hall, Jimmy Z Liu, Mohamed A Almarri, Graeme J Alexander, David E Jones, Richard N Sandford, Carl A Anderson, Heather J Cordell
Formato: Artigo
Idioma:English
Publicado em: Public Library of Science (PLoS) 2018-12-01
coleção:PLoS Genetics
Acesso em linha:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1007833&type=printable

Internet

https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1007833&type=printable

Registros relacionados