Relation between Hormonal Disorders and Components of Metabolic Syndrome in Patients with Primary Hypothyroidism
During the last decade plenty of the researches dedicated to the problem of hypothyroidism were published, that radically changed views to the value of thyroid pathology on the whole. Neurohumoral changes are considered as a nosotropic factor of hypothyroidism development in persons with metabolic s...
| Main Author: | |
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| Format: | Article |
| Language: | English |
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Zaslavsky O.Yu.
2016-09-01
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| Series: | Mìžnarodnij Endokrinologìčnij Žurnal |
| Subjects: | |
| Online Access: | http://iej.zaslavsky.com.ua/article/view/81862 |
| _version_ | 1819001108240007168 |
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| author | Т.Yu. Yuzvenko |
| author_facet | Т.Yu. Yuzvenko |
| author_sort | Т.Yu. Yuzvenko |
| collection | DOAJ |
| description | During the last decade plenty of the researches dedicated to the problem of hypothyroidism were published, that radically changed views to the value of thyroid pathology on the whole. Neurohumoral changes are considered as a nosotropic factor of hypothyroidism development in persons with metabolic syndrome (MS). Aim of the research is to study the features of hormonal disorders and their correlation with the components of metabolic syndrome in patients with primary hypothyroidism. Materials and methods. The study involved 80 patients with primary hypothyroidism: 61 had metabolic syndrome and 19 did not have metabolic syndrome. Results. Statistically significant increased levels of leptin, insulin, cortisol, C-peptide were revealed in patients with hypothyroidism and metabolic syndrome while the most marked changes were found in patients with multiple metabolic abnormalities. Conclusions. The interrelations between hyperleptinemia and fasting glucose, glycated hemoglobin, insulin levels, thyroid-stimulating hormone, index HOMA were determined indicating the modulating role of chronic hyperglycemia, hormonal disorders and insulin resistance in the expression and realization of the biological action of leptin in patients with hypothyroidism and metabolic syndrome. |
| first_indexed | 2024-12-20T22:43:58Z |
| format | Article |
| id | doaj.art-0c3a8ed45fda42cdb8c9519cd06269cb |
| institution | Directory Open Access Journal |
| issn | 2224-0721 2307-1427 |
| language | English |
| last_indexed | 2024-12-20T22:43:58Z |
| publishDate | 2016-09-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Mìžnarodnij Endokrinologìčnij Žurnal |
| spelling | doaj.art-0c3a8ed45fda42cdb8c9519cd06269cb2022-12-21T19:24:24ZengZaslavsky O.Yu.Mìžnarodnij Endokrinologìčnij Žurnal2224-07212307-14272016-09-01126.78667010.22141/2224-0721.6.78.2016.8186281862Relation between Hormonal Disorders and Components of Metabolic Syndrome in Patients with Primary HypothyroidismТ.Yu. Yuzvenko0Ukrainian Research and Practical Centre of Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of Ministry of Health of Ukraine, Kyiv, UkraineDuring the last decade plenty of the researches dedicated to the problem of hypothyroidism were published, that radically changed views to the value of thyroid pathology on the whole. Neurohumoral changes are considered as a nosotropic factor of hypothyroidism development in persons with metabolic syndrome (MS). Aim of the research is to study the features of hormonal disorders and their correlation with the components of metabolic syndrome in patients with primary hypothyroidism. Materials and methods. The study involved 80 patients with primary hypothyroidism: 61 had metabolic syndrome and 19 did not have metabolic syndrome. Results. Statistically significant increased levels of leptin, insulin, cortisol, C-peptide were revealed in patients with hypothyroidism and metabolic syndrome while the most marked changes were found in patients with multiple metabolic abnormalities. Conclusions. The interrelations between hyperleptinemia and fasting glucose, glycated hemoglobin, insulin levels, thyroid-stimulating hormone, index HOMA were determined indicating the modulating role of chronic hyperglycemia, hormonal disorders and insulin resistance in the expression and realization of the biological action of leptin in patients with hypothyroidism and metabolic syndrome.http://iej.zaslavsky.com.ua/article/view/81862hypothyroidismmetabolic syndrome |
| spellingShingle | Т.Yu. Yuzvenko Relation between Hormonal Disorders and Components of Metabolic Syndrome in Patients with Primary Hypothyroidism Mìžnarodnij Endokrinologìčnij Žurnal hypothyroidism metabolic syndrome |
| title | Relation between Hormonal Disorders and Components of Metabolic Syndrome in Patients with Primary Hypothyroidism |
| title_full | Relation between Hormonal Disorders and Components of Metabolic Syndrome in Patients with Primary Hypothyroidism |
| title_fullStr | Relation between Hormonal Disorders and Components of Metabolic Syndrome in Patients with Primary Hypothyroidism |
| title_full_unstemmed | Relation between Hormonal Disorders and Components of Metabolic Syndrome in Patients with Primary Hypothyroidism |
| title_short | Relation between Hormonal Disorders and Components of Metabolic Syndrome in Patients with Primary Hypothyroidism |
| title_sort | relation between hormonal disorders and components of metabolic syndrome in patients with primary hypothyroidism |
| topic | hypothyroidism metabolic syndrome |
| url | http://iej.zaslavsky.com.ua/article/view/81862 |
| work_keys_str_mv | AT tyuyuzvenko relationbetweenhormonaldisordersandcomponentsofmetabolicsyndromeinpatientswithprimaryhypothyroidism |