Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells

Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells

Paclitaxel is a treatment option for advanced or metastatic bladder cancer after the failure of first-line cisplatin and gemcitabine, although resistance limits its clinical benefits. Mcl-1 is an anti-apoptotic protein that promotes resistance to paclitaxel in different tumors. Obatoclax, a BH3 mime...

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Bibliographic Details
Main Authors: Rocío Jiménez-Guerrero, Jessica Gasca, M. Luz Flores, Begoña Pérez-Valderrama, Cristina Tejera-Parrado, Rafael Medina, María Tortolero, Francisco Romero, Miguel A. Japón, Carmen Sáez
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Cancers
Subjects:
bladder cancer
obatoclax
paclitaxel
autophagy
apoptosis
Online Access:https://www.mdpi.com/2072-6694/10/12/490

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