Manganese activates autophagy and microglia M2 polarization against endoplasmic reticulum stress-induced neuroinflammation: Involvement of GSK-3β signaling

Manganese activates autophagy and microglia M2 polarization against endoplasmic reticulum stress-induced neuroinflammation: Involvement of GSK-3β signaling

Background: Endoplasmic reticulum (ER) stress-induced nerve cell damage has been known to be a hallmark feature of Mn-induced parkinsonism pathogenesis. However, several compensatory machineries, such as unfolded protein response (UPR), autophagy, and immune response, play an essential role in this...

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Bibliographic Details
Main Authors: Yuqing Yang, Liang Gao, Jia Meng, Hong Li, Xiaobai Wang, Ying Huang, Jie Wu, Honglin Ma, Dongying Yan
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Manganese
Parkinsonism
ER stress
Autophagy
Microglia polarization
GSK-3β
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223018516

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