Rap1a Activity Elevated the Impact of Endogenous AGEs in Diabetic Collagen to Stimulate Increased Myofibroblast Transition and Oxidative Stress

Rap1a Activity Elevated the Impact of Endogenous AGEs in Diabetic Collagen to Stimulate Increased Myofibroblast Transition and Oxidative Stress

Diabetics have an increased risk for heart failure due to cardiac fibroblast functional changes occurring as a result of AGE/RAGE signaling. Advanced glycation end products (AGEs) levels are higher in diabetics and stimulate elevated RAGE (receptor for AGE) signaling. AGE/RAGE signaling can alter th...

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Bibliographic Details
Main Authors: Stephanie D. Burr, Christopher C. Dorroh, James A. Stewart
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
Rap1a
AGE/RAGE signaling
hyperglycemia
diabetes
cardiac fibroblasts
myofibroblasts
Online Access:https://www.mdpi.com/1422-0067/23/9/4480

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