Pregnancy in a Woman with Homozygous Familial Hypercholesterolemia Not on Low-Density Lipoprotein Apheresis
Pregnancy in women with homozygous familial hypercholesterolemia (FH) has been rarely reported and might pose risks on the mother and her fetus. Although most reported cases remained on low-density lipoprotein (LDL) apheresis, there are no clear guidelines regarding the management of this entity. We...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical Publishers, Inc.
2012-11-01
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| Series: | American Journal of Perinatology Reports |
| Subjects: | |
| Online Access: | https://www.thieme-connect.de/products/ejournals/html/10.1055/s-0032-1305798 |
| _version_ | 1811337054364106752 |
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| author | Akl C. Fahed Anwar H. Nassar |
| author_facet | Akl C. Fahed Anwar H. Nassar |
| author_sort | Akl C. Fahed |
| collection | DOAJ |
| description | Pregnancy in women with homozygous familial hypercholesterolemia (FH) has been rarely reported and might pose risks on the mother and her fetus. Although most reported cases remained on low-density lipoprotein (LDL) apheresis, there are no clear guidelines regarding the management of this entity. We report the first case of an uncomplicated pregnancy in a 24-year-old homozygous FH woman who was not maintained on LDL apheresis. FH expresses a wide variability in the phenotype, and management of homozygous FH cases who desire to become pregnant should be individualized based on preconceptional assessment with frequent antenatal follow-up. Decisions on management should be made after weighing the risks versus benefits of LDL apheresis. |
| first_indexed | 2024-04-13T17:48:29Z |
| format | Article |
| id | doaj.art-0c451b7866124c70b27126e6c1f5fbac |
| institution | Directory Open Access Journal |
| issn | 2157-6998 2157-7005 |
| language | English |
| last_indexed | 2024-04-13T17:48:29Z |
| publishDate | 2012-11-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | American Journal of Perinatology Reports |
| spelling | doaj.art-0c451b7866124c70b27126e6c1f5fbac2022-12-22T02:36:49ZengThieme Medical Publishers, Inc.American Journal of Perinatology Reports2157-69982157-70052012-11-01020103303610.1055/s-0032-1305798Pregnancy in a Woman with Homozygous Familial Hypercholesterolemia Not on Low-Density Lipoprotein ApheresisAkl C. Fahed0Anwar H. Nassar1Harvard Medical SchoolAmerican University of Beirut Medical CenterPregnancy in women with homozygous familial hypercholesterolemia (FH) has been rarely reported and might pose risks on the mother and her fetus. Although most reported cases remained on low-density lipoprotein (LDL) apheresis, there are no clear guidelines regarding the management of this entity. We report the first case of an uncomplicated pregnancy in a 24-year-old homozygous FH woman who was not maintained on LDL apheresis. FH expresses a wide variability in the phenotype, and management of homozygous FH cases who desire to become pregnant should be individualized based on preconceptional assessment with frequent antenatal follow-up. Decisions on management should be made after weighing the risks versus benefits of LDL apheresis.https://www.thieme-connect.de/products/ejournals/html/10.1055/s-0032-1305798homozygous familial hypercholesterolemiapregnancyLDL apheresisoutcome |
| spellingShingle | Akl C. Fahed Anwar H. Nassar Pregnancy in a Woman with Homozygous Familial Hypercholesterolemia Not on Low-Density Lipoprotein Apheresis American Journal of Perinatology Reports homozygous familial hypercholesterolemia pregnancy LDL apheresis outcome |
| title | Pregnancy in a Woman with Homozygous Familial Hypercholesterolemia Not on Low-Density Lipoprotein Apheresis |
| title_full | Pregnancy in a Woman with Homozygous Familial Hypercholesterolemia Not on Low-Density Lipoprotein Apheresis |
| title_fullStr | Pregnancy in a Woman with Homozygous Familial Hypercholesterolemia Not on Low-Density Lipoprotein Apheresis |
| title_full_unstemmed | Pregnancy in a Woman with Homozygous Familial Hypercholesterolemia Not on Low-Density Lipoprotein Apheresis |
| title_short | Pregnancy in a Woman with Homozygous Familial Hypercholesterolemia Not on Low-Density Lipoprotein Apheresis |
| title_sort | pregnancy in a woman with homozygous familial hypercholesterolemia not on low density lipoprotein apheresis |
| topic | homozygous familial hypercholesterolemia pregnancy LDL apheresis outcome |
| url | https://www.thieme-connect.de/products/ejournals/html/10.1055/s-0032-1305798 |
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