Familial autoimmunity and polyautoimmunity in 60 Brazilian Midwest patients with systemic sclerosis
ABSTRACT Introduction: Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology, characterized by a triad of vascular injury, autoimmunity and tissue fibrosis. It is known that a positive family history is the greatest risk factor already identified for the development of SSc in...
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Sociedade Brasileira de Reumatologia
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| Series: | Revista Brasileira de Reumatologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042016000400314&lng=en&tlng=en |
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| author | Alex Magno Coelho Horimoto Aida Freitas do Carmo Silveira Izaias Pereira da Costa |
| author_facet | Alex Magno Coelho Horimoto Aida Freitas do Carmo Silveira Izaias Pereira da Costa |
| author_sort | Alex Magno Coelho Horimoto |
| collection | DOAJ |
| description | ABSTRACT Introduction: Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology, characterized by a triad of vascular injury, autoimmunity and tissue fibrosis. It is known that a positive family history is the greatest risk factor already identified for the development of SSc in a given individual. Preliminary observation of a high prevalence of polyautoimmunity and of familial autoimmunity in SSc patients support the idea that different autoimmune phenotypes may share common susceptibility variants. Objectives: To describe the frequency of familial autoimmunity and polyautoimmunity in 60 SSc patients in the Midwest region of Brazil, as well as to report the main autoimmune diseases observed in this association of comorbidities. Methods: A cross-sectional study with recruitment of 60 consecutive patients selected at the Rheumatology Department, University Hospital, Medicine School, Federal University of Mato Grosso do Sul (FMUFMS), as well as interviews of their relatives during the period from February 2013 to March 2014. Results: A frequency of 43.3% of polyautoimmunity and of 51.7% of familial autoimmunity in SSc patients was found. Patients with the presence of polyautoimmunity and familial autoimmunity presented primarily the diffuse form of SSc, but this indicator did not reach statistical significance. The autoimmune diseases most frequently observed in polyautoimmunity patients were: Hashimoto's thyroiditis (53.8%), Sjögren's syndrome (38.5%), and inflammatory myopathy (11.5%). The main autoimmune diseases observed in SSc patients' relatives were: Hashimoto's thyroiditis (32.3%), rheumatoid arthritis (22.6%), and SLE (22.6%). The presence of more than one autoimmune disease in SSc patients did not correlate with disease severity or activity. Conclusions: From the high prevalence of coexisting autoimmune diseases found in SSc patients, we stress the importance of the concept of shared autoimmunity, in order to promote a continued vigilance and promptly diagnose other possible autoimmune disease in patients, or in their kin. |
| first_indexed | 2024-12-11T12:18:48Z |
| format | Article |
| id | doaj.art-0c4591ad77194dde84ee08d81266bfe3 |
| institution | Directory Open Access Journal |
| issn | 1809-4570 |
| language | English |
| last_indexed | 2024-12-11T12:18:48Z |
| publisher | Sociedade Brasileira de Reumatologia |
| record_format | Article |
| series | Revista Brasileira de Reumatologia |
| spelling | doaj.art-0c4591ad77194dde84ee08d81266bfe32022-12-22T01:07:35ZengSociedade Brasileira de ReumatologiaRevista Brasileira de Reumatologia1809-457056431432210.1016/j.rbre.2016.01.003S0482-50042016000400314Familial autoimmunity and polyautoimmunity in 60 Brazilian Midwest patients with systemic sclerosisAlex Magno Coelho HorimotoAida Freitas do Carmo SilveiraIzaias Pereira da CostaABSTRACT Introduction: Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology, characterized by a triad of vascular injury, autoimmunity and tissue fibrosis. It is known that a positive family history is the greatest risk factor already identified for the development of SSc in a given individual. Preliminary observation of a high prevalence of polyautoimmunity and of familial autoimmunity in SSc patients support the idea that different autoimmune phenotypes may share common susceptibility variants. Objectives: To describe the frequency of familial autoimmunity and polyautoimmunity in 60 SSc patients in the Midwest region of Brazil, as well as to report the main autoimmune diseases observed in this association of comorbidities. Methods: A cross-sectional study with recruitment of 60 consecutive patients selected at the Rheumatology Department, University Hospital, Medicine School, Federal University of Mato Grosso do Sul (FMUFMS), as well as interviews of their relatives during the period from February 2013 to March 2014. Results: A frequency of 43.3% of polyautoimmunity and of 51.7% of familial autoimmunity in SSc patients was found. Patients with the presence of polyautoimmunity and familial autoimmunity presented primarily the diffuse form of SSc, but this indicator did not reach statistical significance. The autoimmune diseases most frequently observed in polyautoimmunity patients were: Hashimoto's thyroiditis (53.8%), Sjögren's syndrome (38.5%), and inflammatory myopathy (11.5%). The main autoimmune diseases observed in SSc patients' relatives were: Hashimoto's thyroiditis (32.3%), rheumatoid arthritis (22.6%), and SLE (22.6%). The presence of more than one autoimmune disease in SSc patients did not correlate with disease severity or activity. Conclusions: From the high prevalence of coexisting autoimmune diseases found in SSc patients, we stress the importance of the concept of shared autoimmunity, in order to promote a continued vigilance and promptly diagnose other possible autoimmune disease in patients, or in their kin.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042016000400314&lng=en&tlng=enAutoantibodiesSystemic sclerosisAutoimmune diseasePolyautoimmunityFamilial autoimmunity |
| spellingShingle | Alex Magno Coelho Horimoto Aida Freitas do Carmo Silveira Izaias Pereira da Costa Familial autoimmunity and polyautoimmunity in 60 Brazilian Midwest patients with systemic sclerosis Revista Brasileira de Reumatologia Autoantibodies Systemic sclerosis Autoimmune disease Polyautoimmunity Familial autoimmunity |
| title | Familial autoimmunity and polyautoimmunity in 60 Brazilian Midwest patients with systemic sclerosis |
| title_full | Familial autoimmunity and polyautoimmunity in 60 Brazilian Midwest patients with systemic sclerosis |
| title_fullStr | Familial autoimmunity and polyautoimmunity in 60 Brazilian Midwest patients with systemic sclerosis |
| title_full_unstemmed | Familial autoimmunity and polyautoimmunity in 60 Brazilian Midwest patients with systemic sclerosis |
| title_short | Familial autoimmunity and polyautoimmunity in 60 Brazilian Midwest patients with systemic sclerosis |
| title_sort | familial autoimmunity and polyautoimmunity in 60 brazilian midwest patients with systemic sclerosis |
| topic | Autoantibodies Systemic sclerosis Autoimmune disease Polyautoimmunity Familial autoimmunity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042016000400314&lng=en&tlng=en |
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