The impact of ultra-high-density mapping on long-term outcome after catheter ablation of ventricular tachycardia
Abstract Ultra-high-density (UHD) mapping can improve scar area detection and fast activation mapping in patients undergoing catheter ablation of ventricular tachycardia (VT). The aim of the present study was to compare the outcome after VT ablation guided by UHD and conventional point-by-point 3D-m...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
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Nature Portfolio
2022-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-12918-7 |
| _version_ | 1817968861915381760 |
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| author | Ruben Schleberger Jana M. Schwarzl Julia Moser Moritz Nies Alexandra Höller Paula Münkler Leon Dinshaw Christiane Jungen Marc D. Lemoine Philippe Maury Frederic Sacher Claire A. Martin Tom Wong Heidi L. Estner Pierre Jaïs Stephan Willems Christian Eickholt Christian Meyer |
| author_facet | Ruben Schleberger Jana M. Schwarzl Julia Moser Moritz Nies Alexandra Höller Paula Münkler Leon Dinshaw Christiane Jungen Marc D. Lemoine Philippe Maury Frederic Sacher Claire A. Martin Tom Wong Heidi L. Estner Pierre Jaïs Stephan Willems Christian Eickholt Christian Meyer |
| author_sort | Ruben Schleberger |
| collection | DOAJ |
| description | Abstract Ultra-high-density (UHD) mapping can improve scar area detection and fast activation mapping in patients undergoing catheter ablation of ventricular tachycardia (VT). The aim of the present study was to compare the outcome after VT ablation guided by UHD and conventional point-by-point 3D-mapping. The acute and long-term ablation outcome of 61 consecutive patients with UHD mapping (64-electrode mini-basket catheter) was compared to 61 consecutive patients with conventional point-by-point 3D-mapping using a 3.5 mm tip catheter. Patients, whose ablation was guided by UHD mapping had an improved 24-months outcome in comparison to patients with conventional mapping (cumulative incidence estimate of the combination of recurrence or disease-related death of 52.4% (95% confidence interval (CI) [36.9–65.7]; recurrence: n = 25; disease-related death: n = 4) versus 69.6% (95% CI [55.9–79.8]); recurrence: n = 31; disease-related death n = 11). In a cause-specific Cox proportional hazards model, UHD mapping (hazard ratio (HR) 0.623; 95% CI [0.390–0.995]; P = 0.048) and left ventricular ejection fraction > 30% (HR 0.485; 95% CI [0.290–0.813]; P = 0.006) were independently associated with lower rates of recurrence or disease-related death. Other procedural parameters were similar in both groups. In conclusion, UHD mapping during VT ablation was associated with fewer VT recurrences or disease-related deaths during long-term follow-up in comparison to conventional point-by-point mapping. Complication rates and other procedural parameters were similar in both groups. |
| first_indexed | 2024-04-13T20:13:20Z |
| format | Article |
| id | doaj.art-0c47e5329b0c4738a9ec2265b17d5657 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T20:13:20Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0c47e5329b0c4738a9ec2265b17d56572022-12-22T02:31:46ZengNature PortfolioScientific Reports2045-23222022-06-011211910.1038/s41598-022-12918-7The impact of ultra-high-density mapping on long-term outcome after catheter ablation of ventricular tachycardiaRuben Schleberger0Jana M. Schwarzl1Julia Moser2Moritz Nies3Alexandra Höller4Paula Münkler5Leon Dinshaw6Christiane Jungen7Marc D. Lemoine8Philippe Maury9Frederic Sacher10Claire A. Martin11Tom Wong12Heidi L. Estner13Pierre Jaïs14Stephan Willems15Christian Eickholt16Christian Meyer17Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-EppendorfDepartment of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-EppendorfDepartment of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-EppendorfDepartment of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-EppendorfCenter of Experimental Medicine, Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-EppendorfDepartment of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-EppendorfDepartment of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-EppendorfDepartment of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-EppendorfDepartment of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-EppendorfDepartment of Cardiology, University Hospital RangueilLIRYC Institute, CHU Bordeaux, University of BordeauxRoyal Papworth Hospital, National Health Service Foundation TrustHeart Rhythm Center, The Royal Brompton and Harefield NHS Foundation Trust, Imperial College LondonDepartment of Internal Medicine I - Cardiology, University Hospital Munich, Ludwig-Maximilian University MunichLIRYC Institute, CHU Bordeaux, University of BordeauxDZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/LübeckDepartment of Cardiology, Asklepios Hospital St. GeorgDZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/LübeckAbstract Ultra-high-density (UHD) mapping can improve scar area detection and fast activation mapping in patients undergoing catheter ablation of ventricular tachycardia (VT). The aim of the present study was to compare the outcome after VT ablation guided by UHD and conventional point-by-point 3D-mapping. The acute and long-term ablation outcome of 61 consecutive patients with UHD mapping (64-electrode mini-basket catheter) was compared to 61 consecutive patients with conventional point-by-point 3D-mapping using a 3.5 mm tip catheter. Patients, whose ablation was guided by UHD mapping had an improved 24-months outcome in comparison to patients with conventional mapping (cumulative incidence estimate of the combination of recurrence or disease-related death of 52.4% (95% confidence interval (CI) [36.9–65.7]; recurrence: n = 25; disease-related death: n = 4) versus 69.6% (95% CI [55.9–79.8]); recurrence: n = 31; disease-related death n = 11). In a cause-specific Cox proportional hazards model, UHD mapping (hazard ratio (HR) 0.623; 95% CI [0.390–0.995]; P = 0.048) and left ventricular ejection fraction > 30% (HR 0.485; 95% CI [0.290–0.813]; P = 0.006) were independently associated with lower rates of recurrence or disease-related death. Other procedural parameters were similar in both groups. In conclusion, UHD mapping during VT ablation was associated with fewer VT recurrences or disease-related deaths during long-term follow-up in comparison to conventional point-by-point mapping. Complication rates and other procedural parameters were similar in both groups.https://doi.org/10.1038/s41598-022-12918-7 |
| spellingShingle | Ruben Schleberger Jana M. Schwarzl Julia Moser Moritz Nies Alexandra Höller Paula Münkler Leon Dinshaw Christiane Jungen Marc D. Lemoine Philippe Maury Frederic Sacher Claire A. Martin Tom Wong Heidi L. Estner Pierre Jaïs Stephan Willems Christian Eickholt Christian Meyer The impact of ultra-high-density mapping on long-term outcome after catheter ablation of ventricular tachycardia Scientific Reports |
| title | The impact of ultra-high-density mapping on long-term outcome after catheter ablation of ventricular tachycardia |
| title_full | The impact of ultra-high-density mapping on long-term outcome after catheter ablation of ventricular tachycardia |
| title_fullStr | The impact of ultra-high-density mapping on long-term outcome after catheter ablation of ventricular tachycardia |
| title_full_unstemmed | The impact of ultra-high-density mapping on long-term outcome after catheter ablation of ventricular tachycardia |
| title_short | The impact of ultra-high-density mapping on long-term outcome after catheter ablation of ventricular tachycardia |
| title_sort | impact of ultra high density mapping on long term outcome after catheter ablation of ventricular tachycardia |
| url | https://doi.org/10.1038/s41598-022-12918-7 |
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