Expression of Interleukin-6 and the Interleukin-6 Receptor Predicts the Clinical Outcomes of Patients with Soft Tissue Sarcomas
Interleukin-6 (IL-6) affects the key parameters of oncogenesis, which increases the cell resistance to apoptosis, the proliferation of cancer cells, angiogenesis, invasion, malignancy, and the ability of tumor cells to respond to anticancer therapy. This study aimed to elucidate the association betw...
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| Format: | Article |
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MDPI AG
2020-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/3/585 |
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| author | Koichi Nakamura Tomoki Nakamura Takahiro Iino Tomohito Hagi Kouji Kita Kunihiro Asanuma Akihiro Sudo |
| author_facet | Koichi Nakamura Tomoki Nakamura Takahiro Iino Tomohito Hagi Kouji Kita Kunihiro Asanuma Akihiro Sudo |
| author_sort | Koichi Nakamura |
| collection | DOAJ |
| description | Interleukin-6 (IL-6) affects the key parameters of oncogenesis, which increases the cell resistance to apoptosis, the proliferation of cancer cells, angiogenesis, invasion, malignancy, and the ability of tumor cells to respond to anticancer therapy. This study aimed to elucidate the association between IL-6 and IL-6 receptor (IL-6R) expression in tissues and clinical outcomes in patients with soft tissue sarcomas (STSs) because, to our knowledge, this has not been done before. We enrolled 86 patients with histologically-proven localized STSs who underwent surgical resection. The cohort included 48 men and 38 women, with a mean age of 65.6 years. The mean follow-up duration was 40.5 months. The expression of IL-6 and IL-6R was immunohistochemically determined. We analyzed prognostic factors for overall survival (OS) and metastasis-free survival (MFS). High IL-6 expression was observed in 23.3% (20/86), high IL-6R expression in 44.2% (38/86), and high expression of both in 16.3% (14/86) of patients. Multivariate analysis showed that a high expression of both IL-6 and IL-6R was a prognostic factor for OS and MFS. We found that this high expression indicated that the patient had a poor prognosis for OS and MFS. |
| first_indexed | 2024-03-12T05:47:08Z |
| format | Article |
| id | doaj.art-0c4ae20a95bc4338a2d84d850f10bbd0 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T05:47:08Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-0c4ae20a95bc4338a2d84d850f10bbd02023-09-03T05:32:10ZengMDPI AGCancers2072-66942020-03-0112358510.3390/cancers12030585cancers12030585Expression of Interleukin-6 and the Interleukin-6 Receptor Predicts the Clinical Outcomes of Patients with Soft Tissue SarcomasKoichi Nakamura0Tomoki Nakamura1Takahiro Iino2Tomohito Hagi3Kouji Kita4Kunihiro Asanuma5Akihiro Sudo6Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu 514-8507, JapanDepartment of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu 514-8507, JapanDepartment of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu 514-8507, JapanDepartment of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu 514-8507, JapanDepartment of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu 514-8507, JapanDepartment of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu 514-8507, JapanDepartment of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu 514-8507, JapanInterleukin-6 (IL-6) affects the key parameters of oncogenesis, which increases the cell resistance to apoptosis, the proliferation of cancer cells, angiogenesis, invasion, malignancy, and the ability of tumor cells to respond to anticancer therapy. This study aimed to elucidate the association between IL-6 and IL-6 receptor (IL-6R) expression in tissues and clinical outcomes in patients with soft tissue sarcomas (STSs) because, to our knowledge, this has not been done before. We enrolled 86 patients with histologically-proven localized STSs who underwent surgical resection. The cohort included 48 men and 38 women, with a mean age of 65.6 years. The mean follow-up duration was 40.5 months. The expression of IL-6 and IL-6R was immunohistochemically determined. We analyzed prognostic factors for overall survival (OS) and metastasis-free survival (MFS). High IL-6 expression was observed in 23.3% (20/86), high IL-6R expression in 44.2% (38/86), and high expression of both in 16.3% (14/86) of patients. Multivariate analysis showed that a high expression of both IL-6 and IL-6R was a prognostic factor for OS and MFS. We found that this high expression indicated that the patient had a poor prognosis for OS and MFS.https://www.mdpi.com/2072-6694/12/3/585soft tissue sarcomainterleukin-6interleukin-6 receptortissue expressionprognosis |
| spellingShingle | Koichi Nakamura Tomoki Nakamura Takahiro Iino Tomohito Hagi Kouji Kita Kunihiro Asanuma Akihiro Sudo Expression of Interleukin-6 and the Interleukin-6 Receptor Predicts the Clinical Outcomes of Patients with Soft Tissue Sarcomas Cancers soft tissue sarcoma interleukin-6 interleukin-6 receptor tissue expression prognosis |
| title | Expression of Interleukin-6 and the Interleukin-6 Receptor Predicts the Clinical Outcomes of Patients with Soft Tissue Sarcomas |
| title_full | Expression of Interleukin-6 and the Interleukin-6 Receptor Predicts the Clinical Outcomes of Patients with Soft Tissue Sarcomas |
| title_fullStr | Expression of Interleukin-6 and the Interleukin-6 Receptor Predicts the Clinical Outcomes of Patients with Soft Tissue Sarcomas |
| title_full_unstemmed | Expression of Interleukin-6 and the Interleukin-6 Receptor Predicts the Clinical Outcomes of Patients with Soft Tissue Sarcomas |
| title_short | Expression of Interleukin-6 and the Interleukin-6 Receptor Predicts the Clinical Outcomes of Patients with Soft Tissue Sarcomas |
| title_sort | expression of interleukin 6 and the interleukin 6 receptor predicts the clinical outcomes of patients with soft tissue sarcomas |
| topic | soft tissue sarcoma interleukin-6 interleukin-6 receptor tissue expression prognosis |
| url | https://www.mdpi.com/2072-6694/12/3/585 |
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