Restoring the DREAM Complex Inhibits the Proliferation of High-Risk HPV Positive Human Cells

Restoring the DREAM Complex Inhibits the Proliferation of High-Risk HPV Positive Human Cells

High-risk (HR) human papillomaviruses are known causative agents in 5% of human cancers including cervical, ano-genital and head and neck carcinomas. In part, HR-HPV causes cancer by targeting host-cell tumor suppressors including retinoblastoma protein (pRb) and RB-like proteins p107 and p130. HR-H...

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Bibliographic Details
Main Authors: Claire D. James, Siddharth Saini, Fatmata Sesay, Kevin Ko, Jessica Felthousen-Rusbasan, Audra N. Iness, Tara Nulton, Brad Windle, Mikhail G. Dozmorov, Iain M. Morgan, Larisa Litovchick
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
human papillomavirus
oncogenic transformation
transcription
cell cycle
protein complex
head and neck cancer
Online Access:https://www.mdpi.com/2072-6694/13/3/489

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