Partial thickness subfoveal hole in a patient treated with tamoxifen: a case report and review of the literature
Abstract Background We describe a patient presenting with a partial thickness subfoveal hole in the right eye after tamoxifen treatment for breast cancer. Case presentation A 76-year-old Caucasian female presented with a 1-day history of acute central scotoma and blurry vision in the right eye. The...
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-022-03681-4 |
| _version_ | 1797977381902745600 |
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| author | Ashley Sohn George Sanchez Dimosthenis Mantopoulos |
| author_facet | Ashley Sohn George Sanchez Dimosthenis Mantopoulos |
| author_sort | Ashley Sohn |
| collection | DOAJ |
| description | Abstract Background We describe a patient presenting with a partial thickness subfoveal hole in the right eye after tamoxifen treatment for breast cancer. Case presentation A 76-year-old Caucasian female presented with a 1-day history of acute central scotoma and blurry vision in the right eye. The patient had been receiving oral tamoxifen for 5 years as adjuvant treatment for stage I lobular breast cancer. Her past ocular history was significant for complete, uneventful, and bilateral posterior vitreous detachment. Clinical examination and optical coherence tomography revealed a new, partial thickness subfoveal hole sparing the inner retinal layers. Observation was recommended. At the last follow-up examination, 1 year after the initial presentation, the subfoveal hole remained stable and visual acuity remained stable. Conclusion Tamoxifen has been associated with a plethora of ophthalmic adverse events, including macular holes, some of which are partial thickness subfoveal holes. Holes with this almost unique morphology are uncommon, and eye care professionals should be aware of this association given the frequency of tamoxifen use, as well as the low success rate of surgical repair with pars plana vitrectomy. |
| first_indexed | 2024-04-11T05:05:59Z |
| format | Article |
| id | doaj.art-0c4ba63e92a44e38a4dbab6da38a7a23 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-04-11T05:05:59Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-0c4ba63e92a44e38a4dbab6da38a7a232022-12-25T12:17:37ZengBMCJournal of Medical Case Reports1752-19472022-12-011611510.1186/s13256-022-03681-4Partial thickness subfoveal hole in a patient treated with tamoxifen: a case report and review of the literatureAshley Sohn0George Sanchez1Dimosthenis Mantopoulos2Geisel School of Medicine at DartmouthGeisel School of Medicine at DartmouthGeisel School of Medicine at DartmouthAbstract Background We describe a patient presenting with a partial thickness subfoveal hole in the right eye after tamoxifen treatment for breast cancer. Case presentation A 76-year-old Caucasian female presented with a 1-day history of acute central scotoma and blurry vision in the right eye. The patient had been receiving oral tamoxifen for 5 years as adjuvant treatment for stage I lobular breast cancer. Her past ocular history was significant for complete, uneventful, and bilateral posterior vitreous detachment. Clinical examination and optical coherence tomography revealed a new, partial thickness subfoveal hole sparing the inner retinal layers. Observation was recommended. At the last follow-up examination, 1 year after the initial presentation, the subfoveal hole remained stable and visual acuity remained stable. Conclusion Tamoxifen has been associated with a plethora of ophthalmic adverse events, including macular holes, some of which are partial thickness subfoveal holes. Holes with this almost unique morphology are uncommon, and eye care professionals should be aware of this association given the frequency of tamoxifen use, as well as the low success rate of surgical repair with pars plana vitrectomy.https://doi.org/10.1186/s13256-022-03681-4TamoxifenMacular holeMacular cystRetinal toxicity |
| spellingShingle | Ashley Sohn George Sanchez Dimosthenis Mantopoulos Partial thickness subfoveal hole in a patient treated with tamoxifen: a case report and review of the literature Journal of Medical Case Reports Tamoxifen Macular hole Macular cyst Retinal toxicity |
| title | Partial thickness subfoveal hole in a patient treated with tamoxifen: a case report and review of the literature |
| title_full | Partial thickness subfoveal hole in a patient treated with tamoxifen: a case report and review of the literature |
| title_fullStr | Partial thickness subfoveal hole in a patient treated with tamoxifen: a case report and review of the literature |
| title_full_unstemmed | Partial thickness subfoveal hole in a patient treated with tamoxifen: a case report and review of the literature |
| title_short | Partial thickness subfoveal hole in a patient treated with tamoxifen: a case report and review of the literature |
| title_sort | partial thickness subfoveal hole in a patient treated with tamoxifen a case report and review of the literature |
| topic | Tamoxifen Macular hole Macular cyst Retinal toxicity |
| url | https://doi.org/10.1186/s13256-022-03681-4 |
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