Targeted Therapy for SLE—What Works, What Doesn’t, What’s Next
For many years, the failure of randomized controlled trials (RCTs) has prevented patients with systemic lupus erythematosus (SLE) from benefiting from biological drugs that have proved to be effective in other rheumatological diseases. Only two biologics are approved for SLE, however they can only b...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/12/9/3198 |
| _version_ | 1797602278530613248 |
|---|---|
| author | Veronica Venturelli David Alan Isenberg |
| author_facet | Veronica Venturelli David Alan Isenberg |
| author_sort | Veronica Venturelli |
| collection | DOAJ |
| description | For many years, the failure of randomized controlled trials (RCTs) has prevented patients with systemic lupus erythematosus (SLE) from benefiting from biological drugs that have proved to be effective in other rheumatological diseases. Only two biologics are approved for SLE, however they can only be administered to a restricted proportion of patients. Recently, several phase II RCTs have evaluated the efficacy and safety of new biologics in extra-renal SLE and lupus nephritis. Six drug trials have reported encouraging results, with an improvement in multiple clinical and serological outcome measures. The possibility of combining B-cell depletion and anti-BLyS treatment has also been successfully explored. |
| first_indexed | 2024-03-11T04:14:47Z |
| format | Article |
| id | doaj.art-0c4cd9322135480f9242a6e0de5e3175 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T04:14:47Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-0c4cd9322135480f9242a6e0de5e31752023-11-17T23:12:00ZengMDPI AGJournal of Clinical Medicine2077-03832023-04-01129319810.3390/jcm12093198Targeted Therapy for SLE—What Works, What Doesn’t, What’s NextVeronica Venturelli0David Alan Isenberg1Rheumatology Unit, Department of Medical Sciences, Università degli Studi di Ferrara, Azienda Ospedaliero-Universitaria S. Anna, 44124 Cona, ItalyCentre for Rheumatology, Department of Medicine, University College London, London WC1E 6JF, UKFor many years, the failure of randomized controlled trials (RCTs) has prevented patients with systemic lupus erythematosus (SLE) from benefiting from biological drugs that have proved to be effective in other rheumatological diseases. Only two biologics are approved for SLE, however they can only be administered to a restricted proportion of patients. Recently, several phase II RCTs have evaluated the efficacy and safety of new biologics in extra-renal SLE and lupus nephritis. Six drug trials have reported encouraging results, with an improvement in multiple clinical and serological outcome measures. The possibility of combining B-cell depletion and anti-BLyS treatment has also been successfully explored.https://www.mdpi.com/2077-0383/12/9/3198biological therapiescombination therapiestrialssystemic lupus erythematosuslupus nephritis |
| spellingShingle | Veronica Venturelli David Alan Isenberg Targeted Therapy for SLE—What Works, What Doesn’t, What’s Next Journal of Clinical Medicine biological therapies combination therapies trials systemic lupus erythematosus lupus nephritis |
| title | Targeted Therapy for SLE—What Works, What Doesn’t, What’s Next |
| title_full | Targeted Therapy for SLE—What Works, What Doesn’t, What’s Next |
| title_fullStr | Targeted Therapy for SLE—What Works, What Doesn’t, What’s Next |
| title_full_unstemmed | Targeted Therapy for SLE—What Works, What Doesn’t, What’s Next |
| title_short | Targeted Therapy for SLE—What Works, What Doesn’t, What’s Next |
| title_sort | targeted therapy for sle what works what doesn t what s next |
| topic | biological therapies combination therapies trials systemic lupus erythematosus lupus nephritis |
| url | https://www.mdpi.com/2077-0383/12/9/3198 |
| work_keys_str_mv | AT veronicaventurelli targetedtherapyforslewhatworkswhatdoesntwhatsnext AT davidalanisenberg targetedtherapyforslewhatworkswhatdoesntwhatsnext |