Fetal Brain Development: Regulating Processes and Related Malformations
This paper describes the contemporary state of knowledge regarding processes that regulate normal development of the embryonic–fetal central nervous system (CNS). The processes are described according to the developmental timetable: dorsal induction, ventral induction, neurogenesis, neuronal migrati...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/6/809 |
| _version_ | 1827659132143927296 |
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| author | Zvi Leibovitz Tally Lerman-Sagie Leila Haddad |
| author_facet | Zvi Leibovitz Tally Lerman-Sagie Leila Haddad |
| author_sort | Zvi Leibovitz |
| collection | DOAJ |
| description | This paper describes the contemporary state of knowledge regarding processes that regulate normal development of the embryonic–fetal central nervous system (CNS). The processes are described according to the developmental timetable: dorsal induction, ventral induction, neurogenesis, neuronal migration, post-migration neuronal development, and cortical organization. We review the current literature on CNS malformations associated with these regulating processes. We specifically address neural tube defects, holoprosencephaly, malformations of cortical development (including microcephaly, megalencephaly, lissencephaly, cobblestone malformations, gray matter heterotopia, and polymicrogyria), disorders of the corpus callosum, and posterior fossa malformations. Fetal ventriculomegaly, which frequently accompanies these disorders, is also reviewed. Each malformation is described with reference to the etiology, genetic causes, prenatal sonographic imaging, associated anomalies, differential diagnosis, complimentary diagnostic studies, clinical interventions, neurodevelopmental outcome, and life quality. |
| first_indexed | 2024-03-09T23:15:16Z |
| format | Article |
| id | doaj.art-0c4d2d78fd12451294bccf4fcee4e64a |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T23:15:16Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-0c4d2d78fd12451294bccf4fcee4e64a2023-11-23T17:35:48ZengMDPI AGLife2075-17292022-05-0112680910.3390/life12060809Fetal Brain Development: Regulating Processes and Related MalformationsZvi Leibovitz0Tally Lerman-Sagie1Leila Haddad2Obstetrics-Gynecology Ultrasound Unit, Department of Obstetrics and Gynecology, Fetal Neurology Clinic, Wolfson Medical Center, Holon and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 5822012, IsraelObstetrics-Gynecology Ultrasound Unit, Department of Obstetrics and Gynecology, Fetal Neurology Clinic, Wolfson Medical Center, Holon and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 5822012, IsraelObstetrics-Gynecology Ultrasound Unit, Bnai-Zion Medical Center, Rappaport Faculty of Medicine, The Technion, Haifa 31048, IsraelThis paper describes the contemporary state of knowledge regarding processes that regulate normal development of the embryonic–fetal central nervous system (CNS). The processes are described according to the developmental timetable: dorsal induction, ventral induction, neurogenesis, neuronal migration, post-migration neuronal development, and cortical organization. We review the current literature on CNS malformations associated with these regulating processes. We specifically address neural tube defects, holoprosencephaly, malformations of cortical development (including microcephaly, megalencephaly, lissencephaly, cobblestone malformations, gray matter heterotopia, and polymicrogyria), disorders of the corpus callosum, and posterior fossa malformations. Fetal ventriculomegaly, which frequently accompanies these disorders, is also reviewed. Each malformation is described with reference to the etiology, genetic causes, prenatal sonographic imaging, associated anomalies, differential diagnosis, complimentary diagnostic studies, clinical interventions, neurodevelopmental outcome, and life quality.https://www.mdpi.com/2075-1729/12/6/809CNS malformationsbrain developmentfetal neurology |
| spellingShingle | Zvi Leibovitz Tally Lerman-Sagie Leila Haddad Fetal Brain Development: Regulating Processes and Related Malformations Life CNS malformations brain development fetal neurology |
| title | Fetal Brain Development: Regulating Processes and Related Malformations |
| title_full | Fetal Brain Development: Regulating Processes and Related Malformations |
| title_fullStr | Fetal Brain Development: Regulating Processes and Related Malformations |
| title_full_unstemmed | Fetal Brain Development: Regulating Processes and Related Malformations |
| title_short | Fetal Brain Development: Regulating Processes and Related Malformations |
| title_sort | fetal brain development regulating processes and related malformations |
| topic | CNS malformations brain development fetal neurology |
| url | https://www.mdpi.com/2075-1729/12/6/809 |
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