Highly improved pH-Responsive anticancer drug delivery and T2-Weighted MRI imaging by magnetic MOF CuBTC-based nano/microcomposite
Cu-BTC framework has received a considerable attention in recent years as a drug carrier candidate for cancer treatment due to its unique structural properties and promising biocompatibility. However, its intrinsic deficiency for medical imaging potentially limits its bioapplications; To address thi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1071376/full |
| _version_ | 1797851689730965504 |
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| author | Zahra Gharehdaghi Seyed Morteza Naghib Rahmatollah Rahimi Atin Bakhshi Amirhosein Kefayat Armin shamaeizadeh Fatemeh Molaabasi |
| author_facet | Zahra Gharehdaghi Seyed Morteza Naghib Rahmatollah Rahimi Atin Bakhshi Amirhosein Kefayat Armin shamaeizadeh Fatemeh Molaabasi |
| author_sort | Zahra Gharehdaghi |
| collection | DOAJ |
| description | Cu-BTC framework has received a considerable attention in recent years as a drug carrier candidate for cancer treatment due to its unique structural properties and promising biocompatibility. However, its intrinsic deficiency for medical imaging potentially limits its bioapplications; To address this subject, a magnetic nano/microscale MOF has been successfully fabricated by introducing Fe3O4 nanoparticles as an imaging agent into the porous isoreticular MOF [Cu3(BTC)2] as a drug carrier. The synthesized magnetic MOFs exhibits a high loading capacity (40.5%) toward the model anticancer DOX with an excellent pH-responsive drug release. The proposed nanocomposite not only possesses large surface area, high magnetic response, large mesopore volume, high transverse relaxivity (r2) and good stability but also exhibits superior biocompatibility, specific tumor cellular uptake, and significant cancer cell viability inhibitory effect without any targeting agent. It is expected that the synthesized magnetic nano/microcomposite may be used for clinical purposes and can also serve as a platform for photoactive antibacterial therapy ae well as pH/GSH/photo-triple-responsive nanocarrier. |
| first_indexed | 2024-04-09T19:20:45Z |
| format | Article |
| id | doaj.art-0c4db8246873466bac439277e13b2ff8 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-09T19:20:45Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-0c4db8246873466bac439277e13b2ff82023-04-05T09:56:16ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2023-04-011010.3389/fmolb.2023.10713761071376Highly improved pH-Responsive anticancer drug delivery and T2-Weighted MRI imaging by magnetic MOF CuBTC-based nano/microcompositeZahra Gharehdaghi0Seyed Morteza Naghib1Rahmatollah Rahimi2Atin Bakhshi3Amirhosein Kefayat4Armin shamaeizadeh5Fatemeh Molaabasi6Department of Chemistry, Iran University of Science and Technology, Tehran, IranNanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology (IUST), Tehran, IranDepartment of Chemistry, Iran University of Science and Technology, Tehran, IranBiomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, IranBiomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, IranNanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology (IUST), Tehran, IranBiomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, IranCu-BTC framework has received a considerable attention in recent years as a drug carrier candidate for cancer treatment due to its unique structural properties and promising biocompatibility. However, its intrinsic deficiency for medical imaging potentially limits its bioapplications; To address this subject, a magnetic nano/microscale MOF has been successfully fabricated by introducing Fe3O4 nanoparticles as an imaging agent into the porous isoreticular MOF [Cu3(BTC)2] as a drug carrier. The synthesized magnetic MOFs exhibits a high loading capacity (40.5%) toward the model anticancer DOX with an excellent pH-responsive drug release. The proposed nanocomposite not only possesses large surface area, high magnetic response, large mesopore volume, high transverse relaxivity (r2) and good stability but also exhibits superior biocompatibility, specific tumor cellular uptake, and significant cancer cell viability inhibitory effect without any targeting agent. It is expected that the synthesized magnetic nano/microcomposite may be used for clinical purposes and can also serve as a platform for photoactive antibacterial therapy ae well as pH/GSH/photo-triple-responsive nanocarrier.https://www.frontiersin.org/articles/10.3389/fmolb.2023.1071376/fullmagneticmetal-organic frameworkcontrolled releasepH-responsive doxorubicin releasemagnetic resonance imagingmultifunctional nanocomposite |
| spellingShingle | Zahra Gharehdaghi Seyed Morteza Naghib Rahmatollah Rahimi Atin Bakhshi Amirhosein Kefayat Armin shamaeizadeh Fatemeh Molaabasi Highly improved pH-Responsive anticancer drug delivery and T2-Weighted MRI imaging by magnetic MOF CuBTC-based nano/microcomposite Frontiers in Molecular Biosciences magnetic metal-organic framework controlled release pH-responsive doxorubicin release magnetic resonance imaging multifunctional nanocomposite |
| title | Highly improved pH-Responsive anticancer drug delivery and T2-Weighted MRI imaging by magnetic MOF CuBTC-based nano/microcomposite |
| title_full | Highly improved pH-Responsive anticancer drug delivery and T2-Weighted MRI imaging by magnetic MOF CuBTC-based nano/microcomposite |
| title_fullStr | Highly improved pH-Responsive anticancer drug delivery and T2-Weighted MRI imaging by magnetic MOF CuBTC-based nano/microcomposite |
| title_full_unstemmed | Highly improved pH-Responsive anticancer drug delivery and T2-Weighted MRI imaging by magnetic MOF CuBTC-based nano/microcomposite |
| title_short | Highly improved pH-Responsive anticancer drug delivery and T2-Weighted MRI imaging by magnetic MOF CuBTC-based nano/microcomposite |
| title_sort | highly improved ph responsive anticancer drug delivery and t2 weighted mri imaging by magnetic mof cubtc based nano microcomposite |
| topic | magnetic metal-organic framework controlled release pH-responsive doxorubicin release magnetic resonance imaging multifunctional nanocomposite |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1071376/full |
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