A Multiple Synergic Treatment for Non-Healing Ulcer Management in a Patient with <i>Klippel–Trenaunay</i> Syndrome
Klippel–Trenanauy syndrome (KTS) is a rare genetic disease determined by overexpression of the phosphatidylinositol-4-5-bisphosphate 3 kinase catalytic subunit (PIK3CA) gene. The clinical presentation is characterized by venous and capillary malformations and lymphatic malformation. To date, no defi...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | Reports |
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| Online Access: | https://www.mdpi.com/2571-841X/6/3/33 |
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| author | Cristina Vocca Gianmarco Marcianò Vincenzo Rania Luca Catarisano Caterina Palleria Salvatore Ciranni Giuseppina Torcia Raffaele Serra Francesco Monea Giuseppe Spaziano Giovambattista De Sarro Rita Citraro Luca Gallelli |
| author_facet | Cristina Vocca Gianmarco Marcianò Vincenzo Rania Luca Catarisano Caterina Palleria Salvatore Ciranni Giuseppina Torcia Raffaele Serra Francesco Monea Giuseppe Spaziano Giovambattista De Sarro Rita Citraro Luca Gallelli |
| author_sort | Cristina Vocca |
| collection | DOAJ |
| description | Klippel–Trenanauy syndrome (KTS) is a rare genetic disease determined by overexpression of the phosphatidylinositol-4-5-bisphosphate 3 kinase catalytic subunit (PIK3CA) gene. The clinical presentation is characterized by venous and capillary malformations and lymphatic malformation. To date, no definitive treatment has been suggested in order to improve the clinical symptoms related to the developments of a skin wound. In this case, we describe a young man with KTS that developed a severe skin wound in the lower right limb unresponsive to the common treatment but responsive to a treatment with oxygen-ozone therapy, pulsed magnetic fields (diamagnetic treatment), and topical fixed association of cocum caprylate, oleic acid, quercetin, and 18-β glycyrrhetinic acid. This is the first case that supports a multistep approach to treat a rare and severe disease, and we hope that other studies can support our data. |
| first_indexed | 2024-03-10T22:03:55Z |
| format | Article |
| id | doaj.art-0c4e312eda984f028250f2c1949b2e79 |
| institution | Directory Open Access Journal |
| issn | 2571-841X |
| language | English |
| last_indexed | 2024-03-10T22:03:55Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Reports |
| spelling | doaj.art-0c4e312eda984f028250f2c1949b2e792023-11-19T12:50:40ZengMDPI AGReports2571-841X2023-07-01633310.3390/reports6030033A Multiple Synergic Treatment for Non-Healing Ulcer Management in a Patient with <i>Klippel–Trenaunay</i> SyndromeCristina Vocca0Gianmarco Marcianò1Vincenzo Rania2Luca Catarisano3Caterina Palleria4Salvatore Ciranni5Giuseppina Torcia6Raffaele Serra7Francesco Monea8Giuseppe Spaziano9Giovambattista De Sarro10Rita Citraro11Luca Gallelli12Operative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco University Hospital”, Department of Health Science, University Magna Graecia, 88100 Catanzaro, ItalyOperative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco University Hospital”, Department of Health Science, University Magna Graecia, 88100 Catanzaro, ItalyOperative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco University Hospital”, Department of Health Science, University Magna Graecia, 88100 Catanzaro, ItalyOperative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco University Hospital”, Department of Health Science, University Magna Graecia, 88100 Catanzaro, ItalyOperative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco University Hospital”, Department of Health Science, University Magna Graecia, 88100 Catanzaro, ItalyVascular Surgery Unit, Department of Medical and Surgical Science, University Magna Graecia, 88100 Catanzaro, ItalyVascular Surgery Unit, Department of Medical and Surgical Science, University Magna Graecia, 88100 Catanzaro, ItalyVascular Surgery Unit, Department of Medical and Surgical Science, University Magna Graecia, 88100 Catanzaro, ItalyResearch Center FAS@UMG, Department of Health Science, University Magna Graecia, 88100 Catanzaro, ItalyDepartment of Environmental Biological and Pharmaceutical Sciences and Technologies, University of Campania “Luigi Vanvitelli”, 81100 Caserta, ItalyOperative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco University Hospital”, Department of Health Science, University Magna Graecia, 88100 Catanzaro, ItalyOperative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco University Hospital”, Department of Health Science, University Magna Graecia, 88100 Catanzaro, ItalyOperative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco University Hospital”, Department of Health Science, University Magna Graecia, 88100 Catanzaro, ItalyKlippel–Trenanauy syndrome (KTS) is a rare genetic disease determined by overexpression of the phosphatidylinositol-4-5-bisphosphate 3 kinase catalytic subunit (PIK3CA) gene. The clinical presentation is characterized by venous and capillary malformations and lymphatic malformation. To date, no definitive treatment has been suggested in order to improve the clinical symptoms related to the developments of a skin wound. In this case, we describe a young man with KTS that developed a severe skin wound in the lower right limb unresponsive to the common treatment but responsive to a treatment with oxygen-ozone therapy, pulsed magnetic fields (diamagnetic treatment), and topical fixed association of cocum caprylate, oleic acid, quercetin, and 18-β glycyrrhetinic acid. This is the first case that supports a multistep approach to treat a rare and severe disease, and we hope that other studies can support our data.https://www.mdpi.com/2571-841X/6/3/33Klippel–Trenanauy syndromewoundoxygen-ozone therapypulsed magnetic fieldsnutrients |
| spellingShingle | Cristina Vocca Gianmarco Marcianò Vincenzo Rania Luca Catarisano Caterina Palleria Salvatore Ciranni Giuseppina Torcia Raffaele Serra Francesco Monea Giuseppe Spaziano Giovambattista De Sarro Rita Citraro Luca Gallelli A Multiple Synergic Treatment for Non-Healing Ulcer Management in a Patient with <i>Klippel–Trenaunay</i> Syndrome Reports Klippel–Trenanauy syndrome wound oxygen-ozone therapy pulsed magnetic fields nutrients |
| title | A Multiple Synergic Treatment for Non-Healing Ulcer Management in a Patient with <i>Klippel–Trenaunay</i> Syndrome |
| title_full | A Multiple Synergic Treatment for Non-Healing Ulcer Management in a Patient with <i>Klippel–Trenaunay</i> Syndrome |
| title_fullStr | A Multiple Synergic Treatment for Non-Healing Ulcer Management in a Patient with <i>Klippel–Trenaunay</i> Syndrome |
| title_full_unstemmed | A Multiple Synergic Treatment for Non-Healing Ulcer Management in a Patient with <i>Klippel–Trenaunay</i> Syndrome |
| title_short | A Multiple Synergic Treatment for Non-Healing Ulcer Management in a Patient with <i>Klippel–Trenaunay</i> Syndrome |
| title_sort | multiple synergic treatment for non healing ulcer management in a patient with i klippel trenaunay i syndrome |
| topic | Klippel–Trenanauy syndrome wound oxygen-ozone therapy pulsed magnetic fields nutrients |
| url | https://www.mdpi.com/2571-841X/6/3/33 |
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