Evaluation of controlled hydroxychloroquine releasing performance from calcium-alginate beads
The aim of this study was to develop an effective controlled drug delivery system based on alginate beads for the treatment of autoimmune diseases such as Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE). The present study describes the drug delivery systems to control the effective...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Hitit University
2021-09-01
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| Series: | Hittite Journal of Science and Engineering |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/1841462 |
| _version_ | 1827796129348059136 |
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| author | Canan Armutcu Sena Pişkin |
| author_facet | Canan Armutcu Sena Pişkin |
| author_sort | Canan Armutcu |
| collection | DOAJ |
| description | The aim of this study was to develop an effective controlled drug delivery system based on alginate beads for the treatment of autoimmune diseases such as Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE). The present study describes the drug delivery systems to control the effective uses of hydroxychloroquine (HCQ) by Ca-alginate beads. The characterization techniques were employed to evaluate the physicochemical properties as scanning electron microscopy (SEM), swelling test (S), hydrolytic degradation (weight loss, WL) and Fourier transform infrared-attenuated total reflection (FTIR-ATR). The release studies from alginate beads prepared in various drug dose were carried out in the aqueous solutions at different pH (5–8) and temperature (4-37oC). The approximately half-amount of HCQ in HCQ-AB3 was released in 12 h and about 84.38% was released within 8 days. Kinetic model, Korsmeyer-Peppas was applied to model the HCQ release kinetic of alginate beads, which corresponded to non-Fickian transport mechanism. |
| first_indexed | 2024-03-11T19:03:01Z |
| format | Article |
| id | doaj.art-0c4e3a1c5d1d40d8a605318a3f8ffb64 |
| institution | Directory Open Access Journal |
| issn | 2148-4171 |
| language | English |
| last_indexed | 2024-03-11T19:03:01Z |
| publishDate | 2021-09-01 |
| publisher | Hitit University |
| record_format | Article |
| series | Hittite Journal of Science and Engineering |
| spelling | doaj.art-0c4e3a1c5d1d40d8a605318a3f8ffb642023-10-10T11:17:29ZengHitit UniversityHittite Journal of Science and Engineering2148-41712021-09-018325526310.17350/HJSE19030000236150Evaluation of controlled hydroxychloroquine releasing performance from calcium-alginate beadsCanan Armutcu0Sena Pişkin1HACETTEPE UNIVERSITY, FACULTY OF SCIENCE, DEPARTMENT OF CHEMISTRYHACETTEPE UNIVERSITY, FACULTY OF SCIENCE, DEPARTMENT OF CHEMISTRYThe aim of this study was to develop an effective controlled drug delivery system based on alginate beads for the treatment of autoimmune diseases such as Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE). The present study describes the drug delivery systems to control the effective uses of hydroxychloroquine (HCQ) by Ca-alginate beads. The characterization techniques were employed to evaluate the physicochemical properties as scanning electron microscopy (SEM), swelling test (S), hydrolytic degradation (weight loss, WL) and Fourier transform infrared-attenuated total reflection (FTIR-ATR). The release studies from alginate beads prepared in various drug dose were carried out in the aqueous solutions at different pH (5–8) and temperature (4-37oC). The approximately half-amount of HCQ in HCQ-AB3 was released in 12 h and about 84.38% was released within 8 days. Kinetic model, Korsmeyer-Peppas was applied to model the HCQ release kinetic of alginate beads, which corresponded to non-Fickian transport mechanism.https://dergipark.org.tr/tr/download/article-file/1841462calcium-alginate beadshydroxychloroquinedrug deliveryrasle |
| spellingShingle | Canan Armutcu Sena Pişkin Evaluation of controlled hydroxychloroquine releasing performance from calcium-alginate beads Hittite Journal of Science and Engineering calcium-alginate beads hydroxychloroquine drug delivery ra sle |
| title | Evaluation of controlled hydroxychloroquine releasing performance from calcium-alginate beads |
| title_full | Evaluation of controlled hydroxychloroquine releasing performance from calcium-alginate beads |
| title_fullStr | Evaluation of controlled hydroxychloroquine releasing performance from calcium-alginate beads |
| title_full_unstemmed | Evaluation of controlled hydroxychloroquine releasing performance from calcium-alginate beads |
| title_short | Evaluation of controlled hydroxychloroquine releasing performance from calcium-alginate beads |
| title_sort | evaluation of controlled hydroxychloroquine releasing performance from calcium alginate beads |
| topic | calcium-alginate beads hydroxychloroquine drug delivery ra sle |
| url | https://dergipark.org.tr/tr/download/article-file/1841462 |
| work_keys_str_mv | AT cananarmutcu evaluationofcontrolledhydroxychloroquinereleasingperformancefromcalciumalginatebeads AT senapiskin evaluationofcontrolledhydroxychloroquinereleasingperformancefromcalciumalginatebeads |