Associations between maternal thyroid function in pregnancy and child neurodevelopmental outcomes at 20 months in the Seychelles Child Development Study, Nutrition Cohort 2 (SCDS NC2)
Maternal thyroid hormones facilitate optimal foetal neurodevelopment; however, the exact role of the thyroid hormones on specific cognitive outcomes is unknown. The present study aimed to investigate associations between maternal thyroid function and neurodevelopmental outcomes in the Seychelles Chi...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2021-01-01
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| Series: | Journal of Nutritional Science |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2048679021000665/type/journal_article |
| _version_ | 1811155964623060992 |
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| author | Anna M. Monaghan Maria S. Mulhern Emeir M. Mc Sorley J.J. Strain Theresa Winter Edwin van Wijngaarden Gary J. Myers Philip W. Davidson Conrad Shamlaye Jude Gedeon Alison J. Yeates |
| author_facet | Anna M. Monaghan Maria S. Mulhern Emeir M. Mc Sorley J.J. Strain Theresa Winter Edwin van Wijngaarden Gary J. Myers Philip W. Davidson Conrad Shamlaye Jude Gedeon Alison J. Yeates |
| author_sort | Anna M. Monaghan |
| collection | DOAJ |
| description | Maternal thyroid hormones facilitate optimal foetal neurodevelopment; however, the exact role of the thyroid hormones on specific cognitive outcomes is unknown. The present study aimed to investigate associations between maternal thyroid function and neurodevelopmental outcomes in the Seychelles Child Development Study (SCDS) Nutrition 2 cohort (n 1328). Maternal free thyroid hormones (fT3, fT4 and fTSH) were assessed at 28 weeks’ gestation with a range of child cognitive outcomes analysed at 20 months. Dietary iodine intake was analysed for a subset of women through a Food Frequency Questionnaire. Linear regression analysis was used to test associations between serum concentrations of maternal thyroid hormones and child neurodevelopment outcomes. Thyroid hormones were analysed as continuous data and categorised as quintiles. 95% of mothers had optimal thyroid function based on fTSH concentrations. Overall, the present study shows that maternal thyroid function is not associated with neurodevelopmental outcomes in this high fish-eating population. However, a positive association, using quintiles for fT3, was reported for the Mental Developmental Index, between Q3 v. Q4 (β 0⋅073; P 0⋅043) and for Q3 v. Q5 (β value 0⋅086; P 0⋅018). To conclude, mothers in our cohort, who largely have optimal thyroid function and iodine intakes, appear able to regulate thyroid function throughout pregnancy to meet neurodevelopmental needs. However, it is possible that minor imbalances of fT3, as indicated from our secondary analysis, may impact offspring neurodevelopment. Further investigation of the relationship between maternal thyroid function and infant neurodevelopment is warranted, particularly in populations with different dietary patterns and thereby iodine intakes. |
| first_indexed | 2024-04-10T04:43:37Z |
| format | Article |
| id | doaj.art-0c52cfbc060c4c6f83b96bc0061e37bf |
| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-04-10T04:43:37Z |
| publishDate | 2021-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-0c52cfbc060c4c6f83b96bc0061e37bf2023-03-09T12:38:45ZengCambridge University PressJournal of Nutritional Science2048-67902021-01-011010.1017/jns.2021.66Associations between maternal thyroid function in pregnancy and child neurodevelopmental outcomes at 20 months in the Seychelles Child Development Study, Nutrition Cohort 2 (SCDS NC2)Anna M. Monaghan0https://orcid.org/0000-0001-6728-0332Maria S. Mulhern1Emeir M. Mc Sorley2J.J. Strain3Theresa Winter4Edwin van Wijngaarden5Gary J. Myers6Philip W. Davidson7Conrad Shamlaye8Jude Gedeon9Alison J. Yeates10Nutrition Innovation Centre for Food and Health, Ulster University, Coleraine, UKNutrition Innovation Centre for Food and Health, Ulster University, Coleraine, UKNutrition Innovation Centre for Food and Health, Ulster University, Coleraine, UKNutrition Innovation Centre for Food and Health, Ulster University, Coleraine, UKInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, GermanyDepartment of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USADepartment of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USADepartment of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USAMinsitry of Health, Mahe, Republic of SeychellesChild Development Centre, Ministry of Health, Mahe, Republic of SeychellesNutrition Innovation Centre for Food and Health, Ulster University, Coleraine, UKMaternal thyroid hormones facilitate optimal foetal neurodevelopment; however, the exact role of the thyroid hormones on specific cognitive outcomes is unknown. The present study aimed to investigate associations between maternal thyroid function and neurodevelopmental outcomes in the Seychelles Child Development Study (SCDS) Nutrition 2 cohort (n 1328). Maternal free thyroid hormones (fT3, fT4 and fTSH) were assessed at 28 weeks’ gestation with a range of child cognitive outcomes analysed at 20 months. Dietary iodine intake was analysed for a subset of women through a Food Frequency Questionnaire. Linear regression analysis was used to test associations between serum concentrations of maternal thyroid hormones and child neurodevelopment outcomes. Thyroid hormones were analysed as continuous data and categorised as quintiles. 95% of mothers had optimal thyroid function based on fTSH concentrations. Overall, the present study shows that maternal thyroid function is not associated with neurodevelopmental outcomes in this high fish-eating population. However, a positive association, using quintiles for fT3, was reported for the Mental Developmental Index, between Q3 v. Q4 (β 0⋅073; P 0⋅043) and for Q3 v. Q5 (β value 0⋅086; P 0⋅018). To conclude, mothers in our cohort, who largely have optimal thyroid function and iodine intakes, appear able to regulate thyroid function throughout pregnancy to meet neurodevelopmental needs. However, it is possible that minor imbalances of fT3, as indicated from our secondary analysis, may impact offspring neurodevelopment. Further investigation of the relationship between maternal thyroid function and infant neurodevelopment is warranted, particularly in populations with different dietary patterns and thereby iodine intakes.https://www.cambridge.org/core/product/identifier/S2048679021000665/type/journal_articleCognitive developmentIodineThyroid function |
| spellingShingle | Anna M. Monaghan Maria S. Mulhern Emeir M. Mc Sorley J.J. Strain Theresa Winter Edwin van Wijngaarden Gary J. Myers Philip W. Davidson Conrad Shamlaye Jude Gedeon Alison J. Yeates Associations between maternal thyroid function in pregnancy and child neurodevelopmental outcomes at 20 months in the Seychelles Child Development Study, Nutrition Cohort 2 (SCDS NC2) Journal of Nutritional Science Cognitive development Iodine Thyroid function |
| title | Associations between maternal thyroid function in pregnancy and child neurodevelopmental outcomes at 20 months in the Seychelles Child Development Study, Nutrition Cohort 2 (SCDS NC2) |
| title_full | Associations between maternal thyroid function in pregnancy and child neurodevelopmental outcomes at 20 months in the Seychelles Child Development Study, Nutrition Cohort 2 (SCDS NC2) |
| title_fullStr | Associations between maternal thyroid function in pregnancy and child neurodevelopmental outcomes at 20 months in the Seychelles Child Development Study, Nutrition Cohort 2 (SCDS NC2) |
| title_full_unstemmed | Associations between maternal thyroid function in pregnancy and child neurodevelopmental outcomes at 20 months in the Seychelles Child Development Study, Nutrition Cohort 2 (SCDS NC2) |
| title_short | Associations between maternal thyroid function in pregnancy and child neurodevelopmental outcomes at 20 months in the Seychelles Child Development Study, Nutrition Cohort 2 (SCDS NC2) |
| title_sort | associations between maternal thyroid function in pregnancy and child neurodevelopmental outcomes at 20 months in the seychelles child development study nutrition cohort 2 scds nc2 |
| topic | Cognitive development Iodine Thyroid function |
| url | https://www.cambridge.org/core/product/identifier/S2048679021000665/type/journal_article |
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