Cell-Free Nucleic Acids As Noninvasive Biomarkers For Colorectal Cancer Detection
Cell-free nucleic acids (CFNA) have been reported by several authors in blood, stool and urine of patients with colorectal cancer (CRC). These genetic biomarkers can be an indication of neoplastic colorectal epithelial cells, so they can potentially be used as noninvasive tests for the detection of...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-08-01
|
| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00182/full |
| _version_ | 1818140752054583296 |
|---|---|
| author | Hicham eMansour |
| author_facet | Hicham eMansour |
| author_sort | Hicham eMansour |
| collection | DOAJ |
| description | Cell-free nucleic acids (CFNA) have been reported by several authors in blood, stool and urine of patients with colorectal cancer (CRC). These genetic biomarkers can be an indication of neoplastic colorectal epithelial cells, so they can potentially be used as noninvasive tests for the detection of the disease in CRC patients and monitor their staging, without the need to use heavier and invasive tools. In a number of test-trials, these genetic tests have shown the advantage of non-invasiveness, making them well accepted by most of the patients, without major side effects. They have also shown a promising sensitivity and specificity in the detection of malignant and premalignant neoplasms. Moreover, costs for performing such tests can be very low. Several studies reported and confirmed the proof of the principle for these genetic tests for screening, diagnosis and prognosis; the main challenge of translating this approach from research to clinical laboratory is the validation in large and long-term randomized trials to prove sustainable high sensitivity and specificity. In this paper, we present a review on the noninvasive genetics biomarkers for CRC detection described in the literature and the challenges that can be encountered for validation processes. |
| first_indexed | 2024-12-11T10:48:58Z |
| format | Article |
| id | doaj.art-0c533dcaf9cb4994a3139a10e93e9420 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-11T10:48:58Z |
| publishDate | 2014-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-0c533dcaf9cb4994a3139a10e93e94202022-12-22T01:10:22ZengFrontiers Media S.A.Frontiers in Genetics1664-80212014-08-01510.3389/fgene.2014.0018293630Cell-Free Nucleic Acids As Noninvasive Biomarkers For Colorectal Cancer DetectionHicham eMansour0King Abdullah university of science and technologyCell-free nucleic acids (CFNA) have been reported by several authors in blood, stool and urine of patients with colorectal cancer (CRC). These genetic biomarkers can be an indication of neoplastic colorectal epithelial cells, so they can potentially be used as noninvasive tests for the detection of the disease in CRC patients and monitor their staging, without the need to use heavier and invasive tools. In a number of test-trials, these genetic tests have shown the advantage of non-invasiveness, making them well accepted by most of the patients, without major side effects. They have also shown a promising sensitivity and specificity in the detection of malignant and premalignant neoplasms. Moreover, costs for performing such tests can be very low. Several studies reported and confirmed the proof of the principle for these genetic tests for screening, diagnosis and prognosis; the main challenge of translating this approach from research to clinical laboratory is the validation in large and long-term randomized trials to prove sustainable high sensitivity and specificity. In this paper, we present a review on the noninvasive genetics biomarkers for CRC detection described in the literature and the challenges that can be encountered for validation processes.http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00182/fullMethylationMutationmicroRNAmRNAscreeningcolorectal cancer |
| spellingShingle | Hicham eMansour Cell-Free Nucleic Acids As Noninvasive Biomarkers For Colorectal Cancer Detection Frontiers in Genetics Methylation Mutation microRNA mRNA screening colorectal cancer |
| title | Cell-Free Nucleic Acids As Noninvasive Biomarkers For Colorectal Cancer Detection |
| title_full | Cell-Free Nucleic Acids As Noninvasive Biomarkers For Colorectal Cancer Detection |
| title_fullStr | Cell-Free Nucleic Acids As Noninvasive Biomarkers For Colorectal Cancer Detection |
| title_full_unstemmed | Cell-Free Nucleic Acids As Noninvasive Biomarkers For Colorectal Cancer Detection |
| title_short | Cell-Free Nucleic Acids As Noninvasive Biomarkers For Colorectal Cancer Detection |
| title_sort | cell free nucleic acids as noninvasive biomarkers for colorectal cancer detection |
| topic | Methylation Mutation microRNA mRNA screening colorectal cancer |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00182/full |
| work_keys_str_mv | AT hichamemansour cellfreenucleicacidsasnoninvasivebiomarkersforcolorectalcancerdetection |