4.8 PLACENTAL NA/K-ATPASE INHIBITOR MARINOBUFAGENIN INDUCES ARTERIAL WALL FIBROSIS IN PREECLAMPSIA

4.8 PLACENTAL NA/K-ATPASE INHIBITOR MARINOBUFAGENIN INDUCES ARTERIAL WALL FIBROSIS IN PREECLAMPSIA

Background: Previous studies implicated cardiotonic steroids, including Na/K-ATPase inhibitor marinobufagenin (MBG), in the pathogenesis of preeclampsia (PE). Immunoneutralization of heightened MBG by Digibind, a digoxin antibody, reduces blood pressure (BP) in patients with PE, and anti-MBG monoclo...

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Bibliographic Details
Main Authors: Olga Fedorova, Natalia Aglakova, Yulia Grigorova, Vitalily Reznik, Valintina Zernetkina, Wen Wei, Edward Lakatta, Alexei Bagrov
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Artery Research
Online Access:https://www.atlantis-press.com/article/125930006/view

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