Reconstructing the transcriptional regulatory network of probiotic L. reuteri is enabled by transcriptomics and machine learning

Reconstructing the transcriptional regulatory network of probiotic L. reuteri is enabled by transcriptomics and machine learning

ABSTRACTLimosilactobacillus reuteri, a probiotic microbe instrumental to human health and sustainable food production, adapts to diverse environmental shifts via dynamic gene expression. We applied the independent component analysis (ICA) to 117 RNA-seq data sets to decode its transcriptional regula...

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Bibliographic Details
Main Authors: Jonathan Josephs-Spaulding, Akanksha Rajput, Ying Hefner, Richard Szubin, Archana Balasubramanian, Gaoyuan Li, Daniel C. Zielinski, Leonie Jahn, Morten Sommer, Patrick Phaneuf, Bernhard O. Palsson
Format: Article
Language:English
Published: American Society for Microbiology 2024-03-01
Series:mSystems
Subjects:
L. reuteri
probiotic
machine learning
transcriptome
systems biology
Online Access:https://journals.asm.org/doi/10.1128/msystems.01257-23

Internet

https://journals.asm.org/doi/10.1128/msystems.01257-23

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