Reconstructing the transcriptional regulatory network of probiotic L. reuteri is enabled by transcriptomics and machine learning
ABSTRACTLimosilactobacillus reuteri, a probiotic microbe instrumental to human health and sustainable food production, adapts to diverse environmental shifts via dynamic gene expression. We applied the independent component analysis (ICA) to 117 RNA-seq data sets to decode its transcriptional regula...
Main Authors: | Jonathan Josephs-Spaulding, Akanksha Rajput, Ying Hefner, Richard Szubin, Archana Balasubramanian, Gaoyuan Li, Daniel C. Zielinski, Leonie Jahn, Morten Sommer, Patrick Phaneuf, Bernhard O. Palsson |
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Format: | Article |
Language: | English |
Published: |
American Society for Microbiology
2024-03-01
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Series: | mSystems |
Subjects: | |
Online Access: | https://journals.asm.org/doi/10.1128/msystems.01257-23 |
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