Are medium cut-off membranes the future, or the promising reality for chronic hemodialysis patients?
The development of hemodialysis (HD) membranes has substantially advanced in the last decade. This has resulted in the manufacturing of medium cut-off membranes (MCO) whose internal architecture is based on greater pore size and a smaller diameter, thus promoting the clearance of particles of greate...
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| Format: | Article |
| Language: | English |
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Permanyer
2023-01-01
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| Series: | Revista de Investigación Clínica |
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| Online Access: | https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=479 |
| _version_ | 1797375220823097344 |
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| author | Noemí Del Toro-Cisneros Erick Y. Zuñiga-González Adrián E. Caballero-Islas José A. Geraldo-Murillo Mauricio Arvizu-Hernández Olynka Vega-Vega |
| author_facet | Noemí Del Toro-Cisneros Erick Y. Zuñiga-González Adrián E. Caballero-Islas José A. Geraldo-Murillo Mauricio Arvizu-Hernández Olynka Vega-Vega |
| author_sort | Noemí Del Toro-Cisneros |
| collection | DOAJ |
| description | The development of hemodialysis (HD) membranes has substantially advanced in the last decade. This has resulted in the manufacturing of medium cut-off membranes (MCO) whose internal architecture is based on greater pore size and a smaller diameter, thus promoting the clearance of particles of greater size as well as retrofiltration. Multiple studies have proven their efficacy in the clearance of uremic mid-sized molecules such as B2-microglobulin, free light chains, and some interleukins; this clearance is far superior with MCO membranes when compared with high-flux HD, and similar to that obtained with online hemodiafiltration. This review summarizes the results of the most relevant clinical studies of this membrane in terms of uremic toxin clearance, as well as the features of some clinical outcomes such as quality of life and hospitalizations.
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| first_indexed | 2024-03-08T19:19:07Z |
| format | Article |
| id | doaj.art-0c5612da730f4012b6980cde4643fa1e |
| institution | Directory Open Access Journal |
| issn | 0034-8376 2564-8896 |
| language | English |
| last_indexed | 2024-03-08T19:19:07Z |
| publishDate | 2023-01-01 |
| publisher | Permanyer |
| record_format | Article |
| series | Revista de Investigación Clínica |
| spelling | doaj.art-0c5612da730f4012b6980cde4643fa1e2023-12-26T19:27:29ZengPermanyerRevista de Investigación Clínica0034-83762564-88962023-01-0175610.24875/RIC.23000213Are medium cut-off membranes the future, or the promising reality for chronic hemodialysis patients?Noemí Del Toro-Cisneros0Erick Y. Zuñiga-González1Adrián E. Caballero-Islas2José A. Geraldo-Murillo3Mauricio Arvizu-Hernández4Olynka Vega-Vega5Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Mexico City, MexicoDepartment of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoDepartment of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoDepartment of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoDepartment of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City; School of Medicine and Health Sciences, Tecnológico de Monterrey, Monterrey, NL, MexicoDepartment of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Mexico City, MexicoThe development of hemodialysis (HD) membranes has substantially advanced in the last decade. This has resulted in the manufacturing of medium cut-off membranes (MCO) whose internal architecture is based on greater pore size and a smaller diameter, thus promoting the clearance of particles of greater size as well as retrofiltration. Multiple studies have proven their efficacy in the clearance of uremic mid-sized molecules such as B2-microglobulin, free light chains, and some interleukins; this clearance is far superior with MCO membranes when compared with high-flux HD, and similar to that obtained with online hemodiafiltration. This review summarizes the results of the most relevant clinical studies of this membrane in terms of uremic toxin clearance, as well as the features of some clinical outcomes such as quality of life and hospitalizations. https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=479Medium cut-off dialyzers. Online-hemodiafiltration. Chronic hemodialysis. Internal filtration–back filtration mechanism. Middle molecules. |
| spellingShingle | Noemí Del Toro-Cisneros Erick Y. Zuñiga-González Adrián E. Caballero-Islas José A. Geraldo-Murillo Mauricio Arvizu-Hernández Olynka Vega-Vega Are medium cut-off membranes the future, or the promising reality for chronic hemodialysis patients? Revista de Investigación Clínica Medium cut-off dialyzers. Online-hemodiafiltration. Chronic hemodialysis. Internal filtration–back filtration mechanism. Middle molecules. |
| title | Are medium cut-off membranes the future, or the promising reality for chronic hemodialysis patients? |
| title_full | Are medium cut-off membranes the future, or the promising reality for chronic hemodialysis patients? |
| title_fullStr | Are medium cut-off membranes the future, or the promising reality for chronic hemodialysis patients? |
| title_full_unstemmed | Are medium cut-off membranes the future, or the promising reality for chronic hemodialysis patients? |
| title_short | Are medium cut-off membranes the future, or the promising reality for chronic hemodialysis patients? |
| title_sort | are medium cut off membranes the future or the promising reality for chronic hemodialysis patients |
| topic | Medium cut-off dialyzers. Online-hemodiafiltration. Chronic hemodialysis. Internal filtration–back filtration mechanism. Middle molecules. |
| url | https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=479 |
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