The functions and clinical application potential of exosomes derived from mesenchymal stem cells on wound repair: a review of recent research advances
Wound repair is a complex problem for both clinical practitioners and scientific investigators. Conventional approaches to wound repair have been associated with several limitations, including prolonged treatment duration, high treatment expenses, and significant economic and psychological strain on...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1256687/full |
| _version_ | 1797736995513958400 |
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| author | Xinchi Qin Xinchi Qin Jia He Xiaoxiang Wang Jingru Wang Ronghua Yang Xiaodong Chen Xiaodong Chen |
| author_facet | Xinchi Qin Xinchi Qin Jia He Xiaoxiang Wang Jingru Wang Ronghua Yang Xiaodong Chen Xiaodong Chen |
| author_sort | Xinchi Qin |
| collection | DOAJ |
| description | Wound repair is a complex problem for both clinical practitioners and scientific investigators. Conventional approaches to wound repair have been associated with several limitations, including prolonged treatment duration, high treatment expenses, and significant economic and psychological strain on patients. Consequently, there is a pressing demand for more efficacious and secure treatment modalities to enhance the existing treatment landscapes. In the field of wound repair, cell-free therapy, particularly the use of mesenchymal stem cell-derived exosomes (MSC-Exos), has made notable advancements in recent years. Exosomes, which are small lipid bilayer vesicles discharged by MSCs, harbor bioactive constituents such as proteins, lipids, microRNA (miRNA), and messenger RNA (mRNA). These constituents facilitate material transfer and information exchange between the cells, thereby regulating their biological functions. This article presents a comprehensive survey of the function and mechanisms of MSC-Exos in the context of wound healing, emphasizing their beneficial impact on each phase of the process, including the regulation of the immune response, inhibition of inflammation, promotion of angiogenesis, advancement of cell proliferation and migration, and reduction of scar formation. |
| first_indexed | 2024-03-12T13:21:02Z |
| format | Article |
| id | doaj.art-0c56b21d37404d58ba127ccc980ad8e6 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-12T13:21:02Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Immunology |
| spelling | doaj.art-0c56b21d37404d58ba127ccc980ad8e62023-08-25T18:28:29ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-08-011410.3389/fimmu.2023.12566871256687The functions and clinical application potential of exosomes derived from mesenchymal stem cells on wound repair: a review of recent research advancesXinchi Qin0Xinchi Qin1Jia He2Xiaoxiang Wang3Jingru Wang4Ronghua Yang5Xiaodong Chen6Xiaodong Chen7Zunyi Medical University, Zunyi, ChinaDepartment of Burn Surgery, The First People’s Hospital of Foshan, Foshan, ChinaDepartment of Burn Surgery, The First People’s Hospital of Foshan, Foshan, ChinaDepartment of Burn Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaDepartment of Burn Surgery, The First People’s Hospital of Foshan, Foshan, ChinaDepartment of Burn and Plastic Surgery, Guangzhou First People’s Hospital, South China University of Technology, Guangzhou, ChinaZunyi Medical University, Zunyi, ChinaDepartment of Burn Surgery, The First People’s Hospital of Foshan, Foshan, ChinaWound repair is a complex problem for both clinical practitioners and scientific investigators. Conventional approaches to wound repair have been associated with several limitations, including prolonged treatment duration, high treatment expenses, and significant economic and psychological strain on patients. Consequently, there is a pressing demand for more efficacious and secure treatment modalities to enhance the existing treatment landscapes. In the field of wound repair, cell-free therapy, particularly the use of mesenchymal stem cell-derived exosomes (MSC-Exos), has made notable advancements in recent years. Exosomes, which are small lipid bilayer vesicles discharged by MSCs, harbor bioactive constituents such as proteins, lipids, microRNA (miRNA), and messenger RNA (mRNA). These constituents facilitate material transfer and information exchange between the cells, thereby regulating their biological functions. This article presents a comprehensive survey of the function and mechanisms of MSC-Exos in the context of wound healing, emphasizing their beneficial impact on each phase of the process, including the regulation of the immune response, inhibition of inflammation, promotion of angiogenesis, advancement of cell proliferation and migration, and reduction of scar formation.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1256687/fullmesenchymal stem cell-derived exosomeswound repairhemostasisinflammationimmuneproliferation |
| spellingShingle | Xinchi Qin Xinchi Qin Jia He Xiaoxiang Wang Jingru Wang Ronghua Yang Xiaodong Chen Xiaodong Chen The functions and clinical application potential of exosomes derived from mesenchymal stem cells on wound repair: a review of recent research advances Frontiers in Immunology mesenchymal stem cell-derived exosomes wound repair hemostasis inflammation immune proliferation |
| title | The functions and clinical application potential of exosomes derived from mesenchymal stem cells on wound repair: a review of recent research advances |
| title_full | The functions and clinical application potential of exosomes derived from mesenchymal stem cells on wound repair: a review of recent research advances |
| title_fullStr | The functions and clinical application potential of exosomes derived from mesenchymal stem cells on wound repair: a review of recent research advances |
| title_full_unstemmed | The functions and clinical application potential of exosomes derived from mesenchymal stem cells on wound repair: a review of recent research advances |
| title_short | The functions and clinical application potential of exosomes derived from mesenchymal stem cells on wound repair: a review of recent research advances |
| title_sort | functions and clinical application potential of exosomes derived from mesenchymal stem cells on wound repair a review of recent research advances |
| topic | mesenchymal stem cell-derived exosomes wound repair hemostasis inflammation immune proliferation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1256687/full |
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