Exosome-mediated repair of spinal cord injury: a promising therapeutic strategy
Abstract Spinal cord injury (SCI) is a catastrophic injury to the central nervous system (CNS) that can lead to sensory and motor dysfunction, which seriously affects patients' quality of life and imposes a major economic burden on society. The pathological process of SCI is divided into primar...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-023-03614-y |
| _version_ | 1797363556036902912 |
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| author | Tong Yu Li-Li Yang Ying Zhou Min-Fei Wu Jian-Hang Jiao |
| author_facet | Tong Yu Li-Li Yang Ying Zhou Min-Fei Wu Jian-Hang Jiao |
| author_sort | Tong Yu |
| collection | DOAJ |
| description | Abstract Spinal cord injury (SCI) is a catastrophic injury to the central nervous system (CNS) that can lead to sensory and motor dysfunction, which seriously affects patients' quality of life and imposes a major economic burden on society. The pathological process of SCI is divided into primary and secondary injury, and secondary injury is a cascade of amplified responses triggered by the primary injury. Due to the complexity of the pathological mechanisms of SCI, there is no clear and effective treatment strategy in clinical practice. Exosomes, which are extracellular vesicles of endoplasmic origin with a diameter of 30–150 nm, play a critical role in intercellular communication and have become an ideal vehicle for drug delivery. A growing body of evidence suggests that exosomes have great potential for repairing SCI. In this review, we introduce exosome preparation, functions, and administration routes. In addition, we summarize the effect and mechanism by which various exosomes repair SCI and review the efficacy of exosomes in combination with other strategies to repair SCI. Finally, the challenges and prospects of the use of exosomes to repair SCI are described. |
| first_indexed | 2024-03-08T16:22:58Z |
| format | Article |
| id | doaj.art-0c576498c08445f5960b8f59c57aa476 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-03-08T16:22:58Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-0c576498c08445f5960b8f59c57aa4762024-01-07T12:14:16ZengBMCStem Cell Research & Therapy1757-65122024-01-0115111910.1186/s13287-023-03614-yExosome-mediated repair of spinal cord injury: a promising therapeutic strategyTong Yu0Li-Li Yang1Ying Zhou2Min-Fei Wu3Jian-Hang Jiao4Department of Orthopedic, The Second Norman Bethune Hospital of Jilin UniversityDepartment of Orthopedic, The Second Norman Bethune Hospital of Jilin UniversityDepartment of Operating Room, The Third Hospital of QinhuangdaoDepartment of Orthopedic, The Second Norman Bethune Hospital of Jilin UniversityDepartment of Orthopedic, The Second Norman Bethune Hospital of Jilin UniversityAbstract Spinal cord injury (SCI) is a catastrophic injury to the central nervous system (CNS) that can lead to sensory and motor dysfunction, which seriously affects patients' quality of life and imposes a major economic burden on society. The pathological process of SCI is divided into primary and secondary injury, and secondary injury is a cascade of amplified responses triggered by the primary injury. Due to the complexity of the pathological mechanisms of SCI, there is no clear and effective treatment strategy in clinical practice. Exosomes, which are extracellular vesicles of endoplasmic origin with a diameter of 30–150 nm, play a critical role in intercellular communication and have become an ideal vehicle for drug delivery. A growing body of evidence suggests that exosomes have great potential for repairing SCI. In this review, we introduce exosome preparation, functions, and administration routes. In addition, we summarize the effect and mechanism by which various exosomes repair SCI and review the efficacy of exosomes in combination with other strategies to repair SCI. Finally, the challenges and prospects of the use of exosomes to repair SCI are described.https://doi.org/10.1186/s13287-023-03614-ySpinal cord injuryExosomeRepairMechanism |
| spellingShingle | Tong Yu Li-Li Yang Ying Zhou Min-Fei Wu Jian-Hang Jiao Exosome-mediated repair of spinal cord injury: a promising therapeutic strategy Stem Cell Research & Therapy Spinal cord injury Exosome Repair Mechanism |
| title | Exosome-mediated repair of spinal cord injury: a promising therapeutic strategy |
| title_full | Exosome-mediated repair of spinal cord injury: a promising therapeutic strategy |
| title_fullStr | Exosome-mediated repair of spinal cord injury: a promising therapeutic strategy |
| title_full_unstemmed | Exosome-mediated repair of spinal cord injury: a promising therapeutic strategy |
| title_short | Exosome-mediated repair of spinal cord injury: a promising therapeutic strategy |
| title_sort | exosome mediated repair of spinal cord injury a promising therapeutic strategy |
| topic | Spinal cord injury Exosome Repair Mechanism |
| url | https://doi.org/10.1186/s13287-023-03614-y |
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