Assessing production variability in empty and filled adeno-associated viruses by single molecule mass analyses
Adeno-associated viruses (AAVs) are useful vehicles for gene therapy because of their stability, low immunogenicity. and non-pathogenicity. However, disparity in AAV sample preparations (e.g., in capsid composition, DNA packaging, and impurities) gives rise to product heterogeneity, with possibly un...
Main Authors: | Eduard H.T.M. Ebberink, Alisa Ruisinger, Markus Nuebel, Marco Thomann, Albert J.R. Heck |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2022-12-01
|
Series: | Molecular Therapy: Methods & Clinical Development |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2329050122001620 |
Similar Items
-
Analysis of thermally driven structural changes, genome release, disassembly, and aggregation of recombinant AAV by CDMS
by: Lauren F. Barnes, et al.
Published: (2022-12-01) -
Genome length determination in adeno-associated virus vectors with mass photometry
by: Cornelia Hiemenz, et al.
Published: (2023-12-01) -
Adeno-Associated Virus (AAV) Gene Delivery: Dissecting Molecular Interactions upon Cell Entry
by: Edward E. Large, et al.
Published: (2021-07-01) -
Adeno-Associated Virus Mediated Gene Therapy for Corneal Diseases
by: Prabhakar Bastola, et al.
Published: (2020-08-01) -
Advanced biomanufacturing and evaluation of adeno-associated virus
by: Kai Chen, et al.
Published: (2024-02-01)