COVID-19 Pulmonary Pathology: The Experience of European Pulmonary Pathologists throughout the First Two Waves of the Pandemic
Autoptic studies of patients who died from COVID-19 constitute an important step forward in improving our knowledge in the pathophysiology of SARS-CoV-2 infection. Systematic analyses of lung tissue, the organ primarily targeted by the disease, were mostly performed during the first wave of the pand...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/1/95 |
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| author | Francesco Fortarezza Federica Pezzuto Paul Hofman Izidor Kern Angel Panizo Jan von der Thüsen Sergei Timofeev Gregor Gorkiewicz Sabina Berezowska Laurence de Leval Cristian Ortiz-Villalón Francesca Lunardi Fiorella Calabrese |
| author_facet | Francesco Fortarezza Federica Pezzuto Paul Hofman Izidor Kern Angel Panizo Jan von der Thüsen Sergei Timofeev Gregor Gorkiewicz Sabina Berezowska Laurence de Leval Cristian Ortiz-Villalón Francesca Lunardi Fiorella Calabrese |
| author_sort | Francesco Fortarezza |
| collection | DOAJ |
| description | Autoptic studies of patients who died from COVID-19 constitute an important step forward in improving our knowledge in the pathophysiology of SARS-CoV-2 infection. Systematic analyses of lung tissue, the organ primarily targeted by the disease, were mostly performed during the first wave of the pandemic. Analyses of pathological lesions at different times offer a good opportunity to better understand the disease and how its evolution has been influenced mostly by new SARS-CoV-2 variants or the different therapeutic approaches. In this short report we summarize responses collected from a questionnaire survey that investigated important pathological data during the first two pandemic waves (spring-summer 2020; autumn-winter 2020–2021). The survey was submitted to expert lung pathologists from nine European countries involved in autoptic procedures in both pandemic waves. The frequency of each lung lesion was quite heterogeneous among the participants. However, a higher frequency of pulmonary superinfections, both bacterial and especially fungal, was observed in the second wave compared to the first. Obtaining a deeper knowledge of the pathological lesions at the basis of this complex and severe disease, which change over time, is crucial for correct patient management and treatment. Autoptic examination is a useful tool to achieve this goal. |
| first_indexed | 2024-03-10T01:38:04Z |
| format | Article |
| id | doaj.art-0c59e7a3f5e0458aad6e40f689a1a73b |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T01:38:04Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-0c59e7a3f5e0458aad6e40f689a1a73b2023-11-23T13:28:08ZengMDPI AGDiagnostics2075-44182022-01-011219510.3390/diagnostics12010095COVID-19 Pulmonary Pathology: The Experience of European Pulmonary Pathologists throughout the First Two Waves of the PandemicFrancesco Fortarezza0Federica Pezzuto1Paul Hofman2Izidor Kern3Angel Panizo4Jan von der Thüsen5Sergei Timofeev6Gregor Gorkiewicz7Sabina Berezowska8Laurence de Leval9Cristian Ortiz-Villalón10Francesca Lunardi11Fiorella Calabrese12Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova Medical School, Via A. Gabelli 61, 35121 Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova Medical School, Via A. Gabelli 61, 35121 Padova, ItalyLaboratory of Clinical and Experimental Pathology, FHU OncoAge, Biobank BB-0033-00025, University Côte d’Azur, 06100 Nice, FranceDepartment of Pathology, University Clinic of Respiratory and Allergic Diseases, 4204 Golnik, SloveniaComplejo Hospitalario de Navarra, 31008 Pamplona, Navarra, SpainDepartment of Pathology, Erasmus MC, 3015 Rotterdam, The NetherlandsMoscow City Hospital 40, 81146 Moscow, RussiaInstitute of Pathology, Medical University of Graz, 8036 Graz, AustriaInstitute of Pathology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 25, 1011 Lausanne, SwitzerlandInstitute of Pathology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 25, 1011 Lausanne, SwitzerlandDepartment of Pathology, Karolinska University Hospital, 17177 Solna, SwedenDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova Medical School, Via A. Gabelli 61, 35121 Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova Medical School, Via A. Gabelli 61, 35121 Padova, ItalyAutoptic studies of patients who died from COVID-19 constitute an important step forward in improving our knowledge in the pathophysiology of SARS-CoV-2 infection. Systematic analyses of lung tissue, the organ primarily targeted by the disease, were mostly performed during the first wave of the pandemic. Analyses of pathological lesions at different times offer a good opportunity to better understand the disease and how its evolution has been influenced mostly by new SARS-CoV-2 variants or the different therapeutic approaches. In this short report we summarize responses collected from a questionnaire survey that investigated important pathological data during the first two pandemic waves (spring-summer 2020; autumn-winter 2020–2021). The survey was submitted to expert lung pathologists from nine European countries involved in autoptic procedures in both pandemic waves. The frequency of each lung lesion was quite heterogeneous among the participants. However, a higher frequency of pulmonary superinfections, both bacterial and especially fungal, was observed in the second wave compared to the first. Obtaining a deeper knowledge of the pathological lesions at the basis of this complex and severe disease, which change over time, is crucial for correct patient management and treatment. Autoptic examination is a useful tool to achieve this goal.https://www.mdpi.com/2075-4418/12/1/95COVID-19SARS-CoV-2autopsylung pathologyCAPA |
| spellingShingle | Francesco Fortarezza Federica Pezzuto Paul Hofman Izidor Kern Angel Panizo Jan von der Thüsen Sergei Timofeev Gregor Gorkiewicz Sabina Berezowska Laurence de Leval Cristian Ortiz-Villalón Francesca Lunardi Fiorella Calabrese COVID-19 Pulmonary Pathology: The Experience of European Pulmonary Pathologists throughout the First Two Waves of the Pandemic Diagnostics COVID-19 SARS-CoV-2 autopsy lung pathology CAPA |
| title | COVID-19 Pulmonary Pathology: The Experience of European Pulmonary Pathologists throughout the First Two Waves of the Pandemic |
| title_full | COVID-19 Pulmonary Pathology: The Experience of European Pulmonary Pathologists throughout the First Two Waves of the Pandemic |
| title_fullStr | COVID-19 Pulmonary Pathology: The Experience of European Pulmonary Pathologists throughout the First Two Waves of the Pandemic |
| title_full_unstemmed | COVID-19 Pulmonary Pathology: The Experience of European Pulmonary Pathologists throughout the First Two Waves of the Pandemic |
| title_short | COVID-19 Pulmonary Pathology: The Experience of European Pulmonary Pathologists throughout the First Two Waves of the Pandemic |
| title_sort | covid 19 pulmonary pathology the experience of european pulmonary pathologists throughout the first two waves of the pandemic |
| topic | COVID-19 SARS-CoV-2 autopsy lung pathology CAPA |
| url | https://www.mdpi.com/2075-4418/12/1/95 |
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