Multiple functions of stress granules in viral infection at a glance
Stress granules (SGs) are distinct RNA granules induced by various stresses, which are evolutionarily conserved across species. In general, SGs act as a conservative and essential self-protection mechanism during stress responses. Viruses have a long evolutionary history and viral infections can tri...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-03-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1138864/full |
| _version_ | 1811162471760658432 |
|---|---|
| author | Yuelin Guan Yan Wang Xudong Fu Xudong Fu Guannan Bai Xue Li Jianhua Mao Yongbin Yan Lidan Hu |
| author_facet | Yuelin Guan Yan Wang Xudong Fu Xudong Fu Guannan Bai Xue Li Jianhua Mao Yongbin Yan Lidan Hu |
| author_sort | Yuelin Guan |
| collection | DOAJ |
| description | Stress granules (SGs) are distinct RNA granules induced by various stresses, which are evolutionarily conserved across species. In general, SGs act as a conservative and essential self-protection mechanism during stress responses. Viruses have a long evolutionary history and viral infections can trigger a series of cellular stress responses, which may interact with SG formation. Targeting SGs is believed as one of the critical and conservative measures for viruses to tackle the inhibition of host cells. In this systematic review, we have summarized the role of SGs in viral infection and categorized their relationships into three tables, with a particular focus on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Moreover, we have outlined several kinds of drugs targeting SGs according to different pathways, most of which are potentially effective against SARS-CoV-2. We believe this review would offer a new view for the researchers and clinicians to attempt to develop more efficacious treatments for virus infection, particularly for the treatment of SARS-CoV-2 infection. |
| first_indexed | 2024-04-10T06:31:30Z |
| format | Article |
| id | doaj.art-0c5a33dfce2f48ae905a202e9bf92396 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-10T06:31:30Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-0c5a33dfce2f48ae905a202e9bf923962023-03-01T07:29:06ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-03-011410.3389/fmicb.2023.11388641138864Multiple functions of stress granules in viral infection at a glanceYuelin Guan0Yan Wang1Xudong Fu2Xudong Fu3Guannan Bai4Xue Li5Jianhua Mao6Yongbin Yan7Lidan Hu8The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaThe Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaCenter of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaZhejiang Laboratory for Systems and Precision Medicine, Zhejiang University Medical Center, Hangzhou, Zhejiang, ChinaThe Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Big Data in Health Science School of Public Health and The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaThe Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaState Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University, Beijing, ChinaThe Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaStress granules (SGs) are distinct RNA granules induced by various stresses, which are evolutionarily conserved across species. In general, SGs act as a conservative and essential self-protection mechanism during stress responses. Viruses have a long evolutionary history and viral infections can trigger a series of cellular stress responses, which may interact with SG formation. Targeting SGs is believed as one of the critical and conservative measures for viruses to tackle the inhibition of host cells. In this systematic review, we have summarized the role of SGs in viral infection and categorized their relationships into three tables, with a particular focus on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Moreover, we have outlined several kinds of drugs targeting SGs according to different pathways, most of which are potentially effective against SARS-CoV-2. We believe this review would offer a new view for the researchers and clinicians to attempt to develop more efficacious treatments for virus infection, particularly for the treatment of SARS-CoV-2 infection.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1138864/fullstress granuleviral infectionSARS-CoV-2drug designantiviral drugs |
| spellingShingle | Yuelin Guan Yan Wang Xudong Fu Xudong Fu Guannan Bai Xue Li Jianhua Mao Yongbin Yan Lidan Hu Multiple functions of stress granules in viral infection at a glance Frontiers in Microbiology stress granule viral infection SARS-CoV-2 drug design antiviral drugs |
| title | Multiple functions of stress granules in viral infection at a glance |
| title_full | Multiple functions of stress granules in viral infection at a glance |
| title_fullStr | Multiple functions of stress granules in viral infection at a glance |
| title_full_unstemmed | Multiple functions of stress granules in viral infection at a glance |
| title_short | Multiple functions of stress granules in viral infection at a glance |
| title_sort | multiple functions of stress granules in viral infection at a glance |
| topic | stress granule viral infection SARS-CoV-2 drug design antiviral drugs |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1138864/full |
| work_keys_str_mv | AT yuelinguan multiplefunctionsofstressgranulesinviralinfectionataglance AT yanwang multiplefunctionsofstressgranulesinviralinfectionataglance AT xudongfu multiplefunctionsofstressgranulesinviralinfectionataglance AT xudongfu multiplefunctionsofstressgranulesinviralinfectionataglance AT guannanbai multiplefunctionsofstressgranulesinviralinfectionataglance AT xueli multiplefunctionsofstressgranulesinviralinfectionataglance AT jianhuamao multiplefunctionsofstressgranulesinviralinfectionataglance AT yongbinyan multiplefunctionsofstressgranulesinviralinfectionataglance AT lidanhu multiplefunctionsofstressgranulesinviralinfectionataglance |