| Summary: | Diabetic foot ulcers are one of the most severe complications of diabetes that have imposed great financial and psychological burdens on diabetic patients. A Nocardia rubra cell wall skeleton (Nr-CWS) can be externally applied to accelerate wound healing. However, its clinical application has not yet been reported. Herein, we report two patients with diabetic foot ulcers treated with Nr-CWS. After wound debridement, the wound was covered with a sterile cotton ball infiltrated with an Nr-CWS that was diluted with 2.0 mL of saline. The covers were changed every two days until complete wound healing occurred. The two wounds healed after 3 and 12 weeks, respectively. This article aims to provide a new treatment for diabetic foot ulcers, with the hope that physicians may consider an Nr-CWS as a complementary method for the treatment of chronic wounds.
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