Resting state brain subnetwork relates to prosociality and compassion in adolescents
Adolescence is a crucial time for social development, especially for helping (prosocial) and compassionate behaviors; yet brain networks involved in adolescent prosociality and compassion currently remain underexplored. Here, we sought to evaluate a recently proposed domain-general developmental (Do...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
|
| Series: | Frontiers in Psychology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyg.2022.1012745/full |
| _version_ | 1798027642281132032 |
|---|---|
| author | Benjamin S. Sipes Angela Jakary Yi Li Jeffrey E. Max Jeffrey E. Max Tony T. Yang Olga Tymofiyeva |
| author_facet | Benjamin S. Sipes Angela Jakary Yi Li Jeffrey E. Max Jeffrey E. Max Tony T. Yang Olga Tymofiyeva |
| author_sort | Benjamin S. Sipes |
| collection | DOAJ |
| description | Adolescence is a crucial time for social development, especially for helping (prosocial) and compassionate behaviors; yet brain networks involved in adolescent prosociality and compassion currently remain underexplored. Here, we sought to evaluate a recently proposed domain-general developmental (Do-GooD) network model of prosocial cognition by relating adolescent functional and structural brain networks with prosocial and compassionate disposition. We acquired resting state fMRI and diffusion MRI from 95 adolescents (ages 14–19 years; 46 males; 49 females) along with self-report questionnaires assessing prosociality and compassion. We then applied the Network-Based Statistic (NBS) to inductively investigate whether there is a significant subnetwork related to prosociality and compassion while controlling for age and sex. Based on the Do-GooD model, we expected that this subnetwork would involve connectivity to the ventromedial prefrontal cortex (VMPFC) from three domain-general networks, the default mode network (DMN), the salience network, and the control network, as well as from the DMN to the mirror neuron systems. NBS revealed a significant functional (but not structural) subnetwork related to prosociality and compassion connecting 31 regions (p = 0.02), showing DMN and DLPFC connectivity to the VMPFC; DMN connectivity to mirror neuron systems; and connectivity between the DMN and cerebellum. These findings largely support and extend the Do-GooD model of prosocial cognition in adolescents by further illuminating network-based relationships that have the potential to advance our understanding of brain mechanisms of prosociality. |
| first_indexed | 2024-04-11T18:54:49Z |
| format | Article |
| id | doaj.art-0c5c330670824670a14f70b1e2961455 |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-04-11T18:54:49Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-0c5c330670824670a14f70b1e29614552022-12-22T04:08:13ZengFrontiers Media S.A.Frontiers in Psychology1664-10782022-10-011310.3389/fpsyg.2022.10127451012745Resting state brain subnetwork relates to prosociality and compassion in adolescentsBenjamin S. Sipes0Angela Jakary1Yi Li2Jeffrey E. Max3Jeffrey E. Max4Tony T. Yang5Olga Tymofiyeva6Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Psychiatry, University of California, San Diego, San Diego, CA, United StatesRady Children’s Hospital San Diego, San Diego, CA, United StatesDepartment of Psychiatry and Behavioral Sciences, The Langley Porter Psychiatric Institute, Division of Child and Adolescent Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United StatesAdolescence is a crucial time for social development, especially for helping (prosocial) and compassionate behaviors; yet brain networks involved in adolescent prosociality and compassion currently remain underexplored. Here, we sought to evaluate a recently proposed domain-general developmental (Do-GooD) network model of prosocial cognition by relating adolescent functional and structural brain networks with prosocial and compassionate disposition. We acquired resting state fMRI and diffusion MRI from 95 adolescents (ages 14–19 years; 46 males; 49 females) along with self-report questionnaires assessing prosociality and compassion. We then applied the Network-Based Statistic (NBS) to inductively investigate whether there is a significant subnetwork related to prosociality and compassion while controlling for age and sex. Based on the Do-GooD model, we expected that this subnetwork would involve connectivity to the ventromedial prefrontal cortex (VMPFC) from three domain-general networks, the default mode network (DMN), the salience network, and the control network, as well as from the DMN to the mirror neuron systems. NBS revealed a significant functional (but not structural) subnetwork related to prosociality and compassion connecting 31 regions (p = 0.02), showing DMN and DLPFC connectivity to the VMPFC; DMN connectivity to mirror neuron systems; and connectivity between the DMN and cerebellum. These findings largely support and extend the Do-GooD model of prosocial cognition in adolescents by further illuminating network-based relationships that have the potential to advance our understanding of brain mechanisms of prosociality.https://www.frontiersin.org/articles/10.3389/fpsyg.2022.1012745/fullMRIconnectivity (graph theory)adolescenceprosocialsocial neurosciencecompassion |
| spellingShingle | Benjamin S. Sipes Angela Jakary Yi Li Jeffrey E. Max Jeffrey E. Max Tony T. Yang Olga Tymofiyeva Resting state brain subnetwork relates to prosociality and compassion in adolescents Frontiers in Psychology MRI connectivity (graph theory) adolescence prosocial social neuroscience compassion |
| title | Resting state brain subnetwork relates to prosociality and compassion in adolescents |
| title_full | Resting state brain subnetwork relates to prosociality and compassion in adolescents |
| title_fullStr | Resting state brain subnetwork relates to prosociality and compassion in adolescents |
| title_full_unstemmed | Resting state brain subnetwork relates to prosociality and compassion in adolescents |
| title_short | Resting state brain subnetwork relates to prosociality and compassion in adolescents |
| title_sort | resting state brain subnetwork relates to prosociality and compassion in adolescents |
| topic | MRI connectivity (graph theory) adolescence prosocial social neuroscience compassion |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2022.1012745/full |
| work_keys_str_mv | AT benjaminssipes restingstatebrainsubnetworkrelatestoprosocialityandcompassioninadolescents AT angelajakary restingstatebrainsubnetworkrelatestoprosocialityandcompassioninadolescents AT yili restingstatebrainsubnetworkrelatestoprosocialityandcompassioninadolescents AT jeffreyemax restingstatebrainsubnetworkrelatestoprosocialityandcompassioninadolescents AT jeffreyemax restingstatebrainsubnetworkrelatestoprosocialityandcompassioninadolescents AT tonytyang restingstatebrainsubnetworkrelatestoprosocialityandcompassioninadolescents AT olgatymofiyeva restingstatebrainsubnetworkrelatestoprosocialityandcompassioninadolescents |