Effect of Launaea procumbens on thyroid glands lipid peroxidation and hormonal dysfunction: a randomized control trial
Abstract Background Launaea procumbens (Roxb.) Amin is traditionally used in Pakistan for the treatment of hormonal disorders and oxidative stress. The present study was aimed to evaluate the efficacy of Launaea procumbens methanol extract (LPME) against KBrO3-induced oxidative stress and hormonal d...
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| Format: | Article |
| Language: | English |
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BMC
2017-09-01
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| Series: | Lipids in Health and Disease |
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| Online Access: | http://link.springer.com/article/10.1186/s12944-017-0557-8 |
| _version_ | 1828484170048864256 |
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| author | Rahmat Ali Khan |
| author_facet | Rahmat Ali Khan |
| author_sort | Rahmat Ali Khan |
| collection | DOAJ |
| description | Abstract Background Launaea procumbens (Roxb.) Amin is traditionally used in Pakistan for the treatment of hormonal disorders and oxidative stress. The present study was aimed to evaluate the efficacy of Launaea procumbens methanol extract (LPME) against KBrO3-induced oxidative stress and hormonal dysfunction in thyroid. Methods To examine the effects of LPME against the oxidative stress of KBrO3 in thyroid tissue, 36 male albino rats were used. Protective effects of LPME were observed on thyroid hormonal levels, activities of antioxidant enzymes, lipid peroxidation (TBARS) and DNA damage. Results Treatment with KBrO3 significantly (P < 0.01) reduced the levels of T3 (55.13 ± 1.93) and T4 (14.7 ± 1.78) and increased TSH (55.13 ± 1.93) levels. KBrO3 exposure in rats reduced the activities of antioxidant enzymes viz.; CAT (1.16 ± 0.08); SOD (12.0 ± 0.08), GST (17.7 ± 1.1) and GSR (54.3 ± 2.1) but increased lipid peroxidation (20.3 ± 0.71) and DNA (30.4 ± 2.0) damage. Co-administration of LPME significantly (P < 0.01) improved these alterations with respect to hormonal levels, activities of antioxidant enzymes and lipid peroxidation close to those seen in control rats. Conclusion These results suggest that LPME can protect thyroid tissue against oxidative damage, possibly through the antioxidant effects of its bioactive compounds. |
| first_indexed | 2024-12-11T08:51:09Z |
| format | Article |
| id | doaj.art-0c5e496ed2664573809d9276d4e3264e |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-11T08:51:09Z |
| publishDate | 2017-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-0c5e496ed2664573809d9276d4e3264e2022-12-22T01:14:01ZengBMCLipids in Health and Disease1476-511X2017-09-011611610.1186/s12944-017-0557-8Effect of Launaea procumbens on thyroid glands lipid peroxidation and hormonal dysfunction: a randomized control trialRahmat Ali Khan0Department of Biotechnology, Faculty of Biological Sciences, University of Science and TechnologyAbstract Background Launaea procumbens (Roxb.) Amin is traditionally used in Pakistan for the treatment of hormonal disorders and oxidative stress. The present study was aimed to evaluate the efficacy of Launaea procumbens methanol extract (LPME) against KBrO3-induced oxidative stress and hormonal dysfunction in thyroid. Methods To examine the effects of LPME against the oxidative stress of KBrO3 in thyroid tissue, 36 male albino rats were used. Protective effects of LPME were observed on thyroid hormonal levels, activities of antioxidant enzymes, lipid peroxidation (TBARS) and DNA damage. Results Treatment with KBrO3 significantly (P < 0.01) reduced the levels of T3 (55.13 ± 1.93) and T4 (14.7 ± 1.78) and increased TSH (55.13 ± 1.93) levels. KBrO3 exposure in rats reduced the activities of antioxidant enzymes viz.; CAT (1.16 ± 0.08); SOD (12.0 ± 0.08), GST (17.7 ± 1.1) and GSR (54.3 ± 2.1) but increased lipid peroxidation (20.3 ± 0.71) and DNA (30.4 ± 2.0) damage. Co-administration of LPME significantly (P < 0.01) improved these alterations with respect to hormonal levels, activities of antioxidant enzymes and lipid peroxidation close to those seen in control rats. Conclusion These results suggest that LPME can protect thyroid tissue against oxidative damage, possibly through the antioxidant effects of its bioactive compounds.http://link.springer.com/article/10.1186/s12944-017-0557-8Launaea ProcumbensOxidative stressAntioxidant enzymesT3T4 |
| spellingShingle | Rahmat Ali Khan Effect of Launaea procumbens on thyroid glands lipid peroxidation and hormonal dysfunction: a randomized control trial Lipids in Health and Disease Launaea Procumbens Oxidative stress Antioxidant enzymes T3 T4 |
| title | Effect of Launaea procumbens on thyroid glands lipid peroxidation and hormonal dysfunction: a randomized control trial |
| title_full | Effect of Launaea procumbens on thyroid glands lipid peroxidation and hormonal dysfunction: a randomized control trial |
| title_fullStr | Effect of Launaea procumbens on thyroid glands lipid peroxidation and hormonal dysfunction: a randomized control trial |
| title_full_unstemmed | Effect of Launaea procumbens on thyroid glands lipid peroxidation and hormonal dysfunction: a randomized control trial |
| title_short | Effect of Launaea procumbens on thyroid glands lipid peroxidation and hormonal dysfunction: a randomized control trial |
| title_sort | effect of launaea procumbens on thyroid glands lipid peroxidation and hormonal dysfunction a randomized control trial |
| topic | Launaea Procumbens Oxidative stress Antioxidant enzymes T3 T4 |
| url | http://link.springer.com/article/10.1186/s12944-017-0557-8 |
| work_keys_str_mv | AT rahmatalikhan effectoflaunaeaprocumbensonthyroidglandslipidperoxidationandhormonaldysfunctionarandomizedcontroltrial |