Single-cell protein secretomic signatures as potential correlates to tumor cell lineage evolution and cell-cell interaction
Secreted proteins including cytokines, chemokines and growth factors represent important functional regulators mediating a range of cellular behavior and cell-cell paracrine/autocrine signaling, e.g. in the immunological system, tumor microenvironment or stem cell niche. Detection of these proteins...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-02-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00010/full |
| _version_ | 1818011164352708608 |
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| author | Minsuk eKwak Luye eMu Yao eLu Jonathan J Chen Yu eWu Kara eBrower Kara eBrower Rong eFan Rong eFan |
| author_facet | Minsuk eKwak Luye eMu Yao eLu Jonathan J Chen Yu eWu Kara eBrower Kara eBrower Rong eFan Rong eFan |
| author_sort | Minsuk eKwak |
| collection | DOAJ |
| description | Secreted proteins including cytokines, chemokines and growth factors represent important functional regulators mediating a range of cellular behavior and cell-cell paracrine/autocrine signaling, e.g. in the immunological system, tumor microenvironment or stem cell niche. Detection of these proteins is of great value not only in basic cell biology but also for diagnosis and therapeutic monitoring of human diseases such as cancer. However, due to co-production of multiple effector proteins from a single cell, referred to as polyfunctionality, it is biologically informative to measure a panel of secreted proteins, or secretomic signature, at the level of single cells. Recent evidence further indicates that a genetically-identical cell population can give rise to diverse phenotypic differences. It is known that cytokines, for example, in the immune system define the effector functions and lineage differentiation of immune cells. In this Perspective Article, we hypothesize that protein secretion profile may represent a universal measure to identify the definitive correlate in the larger context of cellular functions to dissect cellular heterogeneity and evolutionary lineage relationship in human cancer. |
| first_indexed | 2024-04-14T06:04:15Z |
| format | Article |
| id | doaj.art-0c5f4891386a4d6190729514c2f11c82 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-14T06:04:15Z |
| publishDate | 2013-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-0c5f4891386a4d6190729514c2f11c822022-12-22T02:08:36ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2013-02-01310.3389/fonc.2013.0001042684Single-cell protein secretomic signatures as potential correlates to tumor cell lineage evolution and cell-cell interactionMinsuk eKwak0Luye eMu1Yao eLu2Jonathan J Chen3Yu eWu4Kara eBrower5Kara eBrower6Rong eFan7Rong eFan8Yale UniversityYale UniversityYale UniversityYale UniversityYale UniversityYale UniversityIsoplexis IncYale UniversityYale Comprehensive Cancer CenterSecreted proteins including cytokines, chemokines and growth factors represent important functional regulators mediating a range of cellular behavior and cell-cell paracrine/autocrine signaling, e.g. in the immunological system, tumor microenvironment or stem cell niche. Detection of these proteins is of great value not only in basic cell biology but also for diagnosis and therapeutic monitoring of human diseases such as cancer. However, due to co-production of multiple effector proteins from a single cell, referred to as polyfunctionality, it is biologically informative to measure a panel of secreted proteins, or secretomic signature, at the level of single cells. Recent evidence further indicates that a genetically-identical cell population can give rise to diverse phenotypic differences. It is known that cytokines, for example, in the immune system define the effector functions and lineage differentiation of immune cells. In this Perspective Article, we hypothesize that protein secretion profile may represent a universal measure to identify the definitive correlate in the larger context of cellular functions to dissect cellular heterogeneity and evolutionary lineage relationship in human cancer.http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00010/fullTumor Microenvironmentintratumor heterogeneityprotein secretion profilesingle-cell anlaysisimmunomonitoring |
| spellingShingle | Minsuk eKwak Luye eMu Yao eLu Jonathan J Chen Yu eWu Kara eBrower Kara eBrower Rong eFan Rong eFan Single-cell protein secretomic signatures as potential correlates to tumor cell lineage evolution and cell-cell interaction Frontiers in Oncology Tumor Microenvironment intratumor heterogeneity protein secretion profile single-cell anlaysis immunomonitoring |
| title | Single-cell protein secretomic signatures as potential correlates to tumor cell lineage evolution and cell-cell interaction |
| title_full | Single-cell protein secretomic signatures as potential correlates to tumor cell lineage evolution and cell-cell interaction |
| title_fullStr | Single-cell protein secretomic signatures as potential correlates to tumor cell lineage evolution and cell-cell interaction |
| title_full_unstemmed | Single-cell protein secretomic signatures as potential correlates to tumor cell lineage evolution and cell-cell interaction |
| title_short | Single-cell protein secretomic signatures as potential correlates to tumor cell lineage evolution and cell-cell interaction |
| title_sort | single cell protein secretomic signatures as potential correlates to tumor cell lineage evolution and cell cell interaction |
| topic | Tumor Microenvironment intratumor heterogeneity protein secretion profile single-cell anlaysis immunomonitoring |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00010/full |
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