Single-cell protein secretomic signatures as potential correlates to tumor cell lineage evolution and cell-cell interaction

Single-cell protein secretomic signatures as potential correlates to tumor cell lineage evolution and cell-cell interaction

Secreted proteins including cytokines, chemokines and growth factors represent important functional regulators mediating a range of cellular behavior and cell-cell paracrine/autocrine signaling, e.g. in the immunological system, tumor microenvironment or stem cell niche. Detection of these proteins...

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Bibliographic Details
Main Authors: Minsuk eKwak, Luye eMu, Yao eLu, Jonathan J Chen, Yu eWu, Kara eBrower, Rong eFan
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-02-01
Series:Frontiers in Oncology
Subjects:
Tumor Microenvironment
intratumor heterogeneity
protein secretion profile
single-cell anlaysis
immunomonitoring
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00010/full

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