Mdivi-1 attenuates oxidative stress and exerts vascular protection in ischemic/hypoxic injury by a mechanism independent of Drp1 GTPase activity

Mdivi-1 attenuates oxidative stress and exerts vascular protection in ischemic/hypoxic injury by a mechanism independent of Drp1 GTPase activity

Vascular dysfunctions such as vascular hyporeactivity following ischemic/hypoxic injury are a major cause of death in injured patients. In this study, we showed that treatment with mitochondrial division inhibitor 1 (Mdivi-1), a selective inhibitor of dynamin-related protein 1 (Drp1), significantly...

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Bibliographic Details
Main Authors: Chenyang Duan, Li Wang, Jie Zhang, Xinming Xiang, Yue Wu, Zisen Zhang, Qinghui Li, Kunlun Tian, Mingying Xue, Liangming Liu, Tao Li
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Redox Biology
Subjects:
Mdivi-1
Ischemic/hypoxic injury
Drp1
Mitochondrial fission
Oxidative stress
Nrf2
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720309113

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