Glucosamine-Modified Reduction-Responsive Polymeric Micelles for Liver Cancer Therapy
In this work, glucose transporter-1 (GLUT-1) and glutathione (GSH) over-expression in liver cancer was utilized to design a reduction-responsive and active targeting drug delivery system AG-PEG-SS-PCL (APSP) for the delivery of sorafenib (SF). The SF-APSP micelles were prepared using the thin film h...
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MDPI AG
2023-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/9/3824 |
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| author | Lei Meng Fangshu Liu Chenchen Du Jiaying Zhu Qian Xiong Jing Li Weitong Sun |
| author_facet | Lei Meng Fangshu Liu Chenchen Du Jiaying Zhu Qian Xiong Jing Li Weitong Sun |
| author_sort | Lei Meng |
| collection | DOAJ |
| description | In this work, glucose transporter-1 (GLUT-1) and glutathione (GSH) over-expression in liver cancer was utilized to design a reduction-responsive and active targeting drug delivery system AG-PEG-SS-PCL (APSP) for the delivery of sorafenib (SF). The SF-APSP micelles were prepared using the thin film hydration method and characterized by various techniques. In vitro release experiments showed that the cumulative release of SF-APSP micelles in the simulated tumor microenvironment (pH 7.4 with GSH) reached 94.76 ± 1.78% at 48 h, while it was only 20.32 ± 1.67% in the normal physiological environment (pH 7.4 without GSH). The in vitro study revealed that glucosamine (AG) enhanced the antitumor effects of SF, and SF-APSP micelles inhibited proliferation by targeting HepG2 cells and suppressing cyclin D1 expression. The in vivo antitumor efficacy study further confirmed that the SF-APSP micelles had excellent antitumor effects and better tolerance against nude mouse with HepG2 cells than other treatment groups. All in all, these results indicated that SF-APSP micelles could be a promising drug delivery system for anti-hepatoma treatment. |
| first_indexed | 2024-03-11T04:11:47Z |
| format | Article |
| id | doaj.art-0c5fa80e242b4f37ae38fd0a88c73092 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T04:11:47Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
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| series | Molecules |
| spelling | doaj.art-0c5fa80e242b4f37ae38fd0a88c730922023-11-17T23:23:57ZengMDPI AGMolecules1420-30492023-04-01289382410.3390/molecules28093824Glucosamine-Modified Reduction-Responsive Polymeric Micelles for Liver Cancer TherapyLei Meng0Fangshu Liu1Chenchen Du2Jiaying Zhu3Qian Xiong4Jing Li5Weitong Sun6College of Pharmacy, Jiamusi University, Jiamusi 154007, ChinaCollege of Pharmacy, Jiamusi University, Jiamusi 154007, ChinaCollege of Pharmacy, Jiamusi University, Jiamusi 154007, ChinaCollege of Pharmacy, Jiamusi University, Jiamusi 154007, ChinaCollege of Pharmacy, Jiamusi University, Jiamusi 154007, ChinaCollege of Pharmacy, Jiamusi University, Jiamusi 154007, ChinaCollege of Pharmacy, Jiamusi University, Jiamusi 154007, ChinaIn this work, glucose transporter-1 (GLUT-1) and glutathione (GSH) over-expression in liver cancer was utilized to design a reduction-responsive and active targeting drug delivery system AG-PEG-SS-PCL (APSP) for the delivery of sorafenib (SF). The SF-APSP micelles were prepared using the thin film hydration method and characterized by various techniques. In vitro release experiments showed that the cumulative release of SF-APSP micelles in the simulated tumor microenvironment (pH 7.4 with GSH) reached 94.76 ± 1.78% at 48 h, while it was only 20.32 ± 1.67% in the normal physiological environment (pH 7.4 without GSH). The in vitro study revealed that glucosamine (AG) enhanced the antitumor effects of SF, and SF-APSP micelles inhibited proliferation by targeting HepG2 cells and suppressing cyclin D1 expression. The in vivo antitumor efficacy study further confirmed that the SF-APSP micelles had excellent antitumor effects and better tolerance against nude mouse with HepG2 cells than other treatment groups. All in all, these results indicated that SF-APSP micelles could be a promising drug delivery system for anti-hepatoma treatment.https://www.mdpi.com/1420-3049/28/9/3824liver cancerglucosaminesorafenibreduction-responsivepolymer micelles |
| spellingShingle | Lei Meng Fangshu Liu Chenchen Du Jiaying Zhu Qian Xiong Jing Li Weitong Sun Glucosamine-Modified Reduction-Responsive Polymeric Micelles for Liver Cancer Therapy Molecules liver cancer glucosamine sorafenib reduction-responsive polymer micelles |
| title | Glucosamine-Modified Reduction-Responsive Polymeric Micelles for Liver Cancer Therapy |
| title_full | Glucosamine-Modified Reduction-Responsive Polymeric Micelles for Liver Cancer Therapy |
| title_fullStr | Glucosamine-Modified Reduction-Responsive Polymeric Micelles for Liver Cancer Therapy |
| title_full_unstemmed | Glucosamine-Modified Reduction-Responsive Polymeric Micelles for Liver Cancer Therapy |
| title_short | Glucosamine-Modified Reduction-Responsive Polymeric Micelles for Liver Cancer Therapy |
| title_sort | glucosamine modified reduction responsive polymeric micelles for liver cancer therapy |
| topic | liver cancer glucosamine sorafenib reduction-responsive polymer micelles |
| url | https://www.mdpi.com/1420-3049/28/9/3824 |
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