Biochemical effect of the Biophosphomag medication on the biochemical blood indicators in rats under oxidative stress conditions
The study was aimed to examine the effects of the Biophosphomag medication on biochemical parameters of blood under induced oxidative stress in rats. For this purpose, we used 24 animals weighing 200±20 g. The animals were divided into 4 groups of 6 animals in each one and kept on a standard diet wi...
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| Format: | Article |
| Language: | English |
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Institute of Animal Biology NAAS
2022-10-01
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| Series: | Біологія тварин |
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| Online Access: | https://aminbiol.com.ua/index.php/archive/191-archive/bt-24-3-2022/2033-biochemical-effect-of-the-biophosphomag-medication-on-the-biochemical-blood-indicators-in-rats-under-oxidative-stress-conditions |
| _version_ | 1827397557610872832 |
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| author | R. I. Palonko |
| author_facet | R. I. Palonko |
| author_sort | R. I. Palonko |
| collection | DOAJ |
| description | The study was aimed to examine the effects of the Biophosphomag medication on biochemical parameters of blood under induced oxidative stress in rats. For this purpose, we used 24 animals weighing 200±20 g. The animals were divided into 4 groups of 6 animals in each one and kept on a standard diet with access to water ad libitum. The 1st group was an intact control without oxidative stress and its correction; the 2nd was a control with induced oxidative stress and without its correction. The 3rd group received a 1% solution of magnesium sulfate intragastrically. The animals of the 4th group were administered Biophosphomag (a combined medication of magnesium and phosphorus based on casein) in a dose equivalent to magnesium sulfate by magnesium. Oxidative stress was induced with a single intragastric administration of paracetamol. The results of the serum analysis after the intake of medication showed, on the one hand, a decrease in the activity of the enzymes: alkaline phosphatase, alanine aminotransferase, α-amylase, aspartate aminotransferase, lactate dehydrogenase, glucose and TBA-active compounds concentration (P<0.05), and, on the other hand, an increase in the magnesium concentration and catalase activity. The obtained results indicate a higher bioavailability of magnesium in the composition of the Biophosphomag medication than in the composition of magnesium sulfate, which leads to a more significant hepatoprotective effect under conditions of induced oxidative damage to the liver. They can be an argument why Biophosphomag medication should be used in the correction of pathological processes accompanied by oxidative stress or as a source of magnesium with high bioavailability. |
| first_indexed | 2024-03-08T19:10:14Z |
| format | Article |
| id | doaj.art-0c61ccf702524a3199d16a88328534f7 |
| institution | Directory Open Access Journal |
| issn | 1681-0015 2313-2191 |
| language | English |
| last_indexed | 2024-03-08T19:10:14Z |
| publishDate | 2022-10-01 |
| publisher | Institute of Animal Biology NAAS |
| record_format | Article |
| series | Біологія тварин |
| spelling | doaj.art-0c61ccf702524a3199d16a88328534f72023-12-27T14:31:57ZengInstitute of Animal Biology NAASБіологія тварин1681-00152313-21912022-10-01243394310.15407/animbiol24.03.039Biochemical effect of the Biophosphomag medication on the biochemical blood indicators in rats under oxidative stress conditionsR. I. Palonko0https://orcid.org/0000-0001-5275-5366National University of Life and Environmental Sciences of UkraineThe study was aimed to examine the effects of the Biophosphomag medication on biochemical parameters of blood under induced oxidative stress in rats. For this purpose, we used 24 animals weighing 200±20 g. The animals were divided into 4 groups of 6 animals in each one and kept on a standard diet with access to water ad libitum. The 1st group was an intact control without oxidative stress and its correction; the 2nd was a control with induced oxidative stress and without its correction. The 3rd group received a 1% solution of magnesium sulfate intragastrically. The animals of the 4th group were administered Biophosphomag (a combined medication of magnesium and phosphorus based on casein) in a dose equivalent to magnesium sulfate by magnesium. Oxidative stress was induced with a single intragastric administration of paracetamol. The results of the serum analysis after the intake of medication showed, on the one hand, a decrease in the activity of the enzymes: alkaline phosphatase, alanine aminotransferase, α-amylase, aspartate aminotransferase, lactate dehydrogenase, glucose and TBA-active compounds concentration (P<0.05), and, on the other hand, an increase in the magnesium concentration and catalase activity. The obtained results indicate a higher bioavailability of magnesium in the composition of the Biophosphomag medication than in the composition of magnesium sulfate, which leads to a more significant hepatoprotective effect under conditions of induced oxidative damage to the liver. They can be an argument why Biophosphomag medication should be used in the correction of pathological processes accompanied by oxidative stress or as a source of magnesium with high bioavailability.https://aminbiol.com.ua/index.php/archive/191-archive/bt-24-3-2022/2033-biochemical-effect-of-the-biophosphomag-medication-on-the-biochemical-blood-indicators-in-rats-under-oxidative-stress-conditionsоксидативний стресактивні форми киснювідновлений глутатіонантиоксидантний захистхелатoxidative stressreactive oxygen speciesglutathioneantioxidant protectionchelate |
| spellingShingle | R. I. Palonko Biochemical effect of the Biophosphomag medication on the biochemical blood indicators in rats under oxidative stress conditions Біологія тварин оксидативний стрес активні форми кисню відновлений глутатіон антиоксидантний захист хелат oxidative stress reactive oxygen species glutathione antioxidant protection chelate |
| title | Biochemical effect of the Biophosphomag medication on the biochemical blood indicators in rats under oxidative stress conditions |
| title_full | Biochemical effect of the Biophosphomag medication on the biochemical blood indicators in rats under oxidative stress conditions |
| title_fullStr | Biochemical effect of the Biophosphomag medication on the biochemical blood indicators in rats under oxidative stress conditions |
| title_full_unstemmed | Biochemical effect of the Biophosphomag medication on the biochemical blood indicators in rats under oxidative stress conditions |
| title_short | Biochemical effect of the Biophosphomag medication on the biochemical blood indicators in rats under oxidative stress conditions |
| title_sort | biochemical effect of the biophosphomag medication on the biochemical blood indicators in rats under oxidative stress conditions |
| topic | оксидативний стрес активні форми кисню відновлений глутатіон антиоксидантний захист хелат oxidative stress reactive oxygen species glutathione antioxidant protection chelate |
| url | https://aminbiol.com.ua/index.php/archive/191-archive/bt-24-3-2022/2033-biochemical-effect-of-the-biophosphomag-medication-on-the-biochemical-blood-indicators-in-rats-under-oxidative-stress-conditions |
| work_keys_str_mv | AT ripalonko biochemicaleffectofthebiophosphomagmedicationonthebiochemicalbloodindicatorsinratsunderoxidativestressconditions |