Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India
<p>Abstract</p> <p><b>Background</b></p> <p>Understanding co-receptor tropism of HIV-1 strains circulating in India will provide key analytical leverage for assessing the potential usefulness of newer antiretroviral drugs such as chemokine co-receptor antago...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-07-01
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| Series: | AIDS Research and Therapy |
| Online Access: | http://www.aidsrestherapy.com/content/7/1/24 |
| _version_ | 1818565327282241536 |
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| author | Kuttiatt Vijesh S DeCosta Ayesha D'Souza George Prarthana Sreenivasa B Neogi Ujjwal Ranga Udaykumar Shet Anita |
| author_facet | Kuttiatt Vijesh S DeCosta Ayesha D'Souza George Prarthana Sreenivasa B Neogi Ujjwal Ranga Udaykumar Shet Anita |
| author_sort | Kuttiatt Vijesh S |
| collection | DOAJ |
| description | <p>Abstract</p> <p><b>Background</b></p> <p>Understanding co-receptor tropism of HIV-1 strains circulating in India will provide key analytical leverage for assessing the potential usefulness of newer antiretroviral drugs such as chemokine co-receptor antagonists among Indian HIV-infected populations. The objective of this study was to determine using <it>in silico </it>methods, HIV-1 tropism among a large number of Indian isolates both from primary clinical isolates as well as from database-derived sequences.</p> <p>Results</p> <p>R5-tropism was seen in 96.8% of a total of 1045 HIV-1 subtype C Indian sequences. Co-receptor prediction of 15 primary clinical isolates detected two X4-tropic strains using the C-PSSM matrix. R5-tropic HIV-1 subtype C V3 sequences were conserved to a greater extent than X4-tropic strains. X4-tropic strains were obtained from subjects who had a significantly longer time since HIV diagnosis (96.5 months) compared to R5-tropic strains (20.5 months).</p> <p>Conclusions</p> <p>High prevalence of R5 tropism and greater homogeneity of the V3 sequence among HIV-1 subtype C strains in India suggests the potential benefit of CCR5 antagonists as a therapeutic option in India.</p> |
| first_indexed | 2024-12-14T01:39:54Z |
| format | Article |
| id | doaj.art-0c61e8187fae45b08fd98450e24cabc1 |
| institution | Directory Open Access Journal |
| issn | 1742-6405 |
| language | English |
| last_indexed | 2024-12-14T01:39:54Z |
| publishDate | 2010-07-01 |
| publisher | BMC |
| record_format | Article |
| series | AIDS Research and Therapy |
| spelling | doaj.art-0c61e8187fae45b08fd98450e24cabc12022-12-21T23:21:46ZengBMCAIDS Research and Therapy1742-64052010-07-01712410.1186/1742-6405-7-24Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for IndiaKuttiatt Vijesh SDeCosta AyeshaD'Souza GeorgePrarthana Sreenivasa BNeogi UjjwalRanga UdaykumarShet Anita<p>Abstract</p> <p><b>Background</b></p> <p>Understanding co-receptor tropism of HIV-1 strains circulating in India will provide key analytical leverage for assessing the potential usefulness of newer antiretroviral drugs such as chemokine co-receptor antagonists among Indian HIV-infected populations. The objective of this study was to determine using <it>in silico </it>methods, HIV-1 tropism among a large number of Indian isolates both from primary clinical isolates as well as from database-derived sequences.</p> <p>Results</p> <p>R5-tropism was seen in 96.8% of a total of 1045 HIV-1 subtype C Indian sequences. Co-receptor prediction of 15 primary clinical isolates detected two X4-tropic strains using the C-PSSM matrix. R5-tropic HIV-1 subtype C V3 sequences were conserved to a greater extent than X4-tropic strains. X4-tropic strains were obtained from subjects who had a significantly longer time since HIV diagnosis (96.5 months) compared to R5-tropic strains (20.5 months).</p> <p>Conclusions</p> <p>High prevalence of R5 tropism and greater homogeneity of the V3 sequence among HIV-1 subtype C strains in India suggests the potential benefit of CCR5 antagonists as a therapeutic option in India.</p>http://www.aidsrestherapy.com/content/7/1/24 |
| spellingShingle | Kuttiatt Vijesh S DeCosta Ayesha D'Souza George Prarthana Sreenivasa B Neogi Ujjwal Ranga Udaykumar Shet Anita Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India AIDS Research and Therapy |
| title | Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India |
| title_full | Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India |
| title_fullStr | Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India |
| title_full_unstemmed | Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India |
| title_short | Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India |
| title_sort | co receptor tropism prediction among 1045 indian hiv 1 subtype c sequences therapeutic implications for india |
| url | http://www.aidsrestherapy.com/content/7/1/24 |
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