Nodularin Exposure Induces SOD1 Phosphorylation and Disrupts SOD1 Co-localization with Actin Filaments

Nodularin Exposure Induces SOD1 Phosphorylation and Disrupts SOD1 Co-localization with Actin Filaments

Apoptotic cell death is induced in primary hepatocytes by the Ser/Thr protein phosphatase inhibiting cyanobacterial toxin nodularin after only minutes of exposure. Nodularin-induced apoptosis involves a rapid development of reactive oxygen species (ROS), which can be delayed by the Ca2+/calmodulin p...

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Bibliographic Details
Main Authors: Kari E. Fladmark, Therese Solstad, Fiona M. Young, Lise Fismen, Linda V. Hjørnevik
Format: Article
Language:English
Published: MDPI AG 2012-12-01
Series:Toxins
Subjects:
nodularin
apoptosis
SOD1
phosphorylation
actin
ROS
Online Access:http://www.mdpi.com/2072-6651/4/12/1482

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