Metabolic Profile and Pathological Alterations in the Muscle of Patients with Early-Stage Amyotrophic Lateral Sclerosis

Metabolic Profile and Pathological Alterations in the Muscle of Patients with Early-Stage Amyotrophic Lateral Sclerosis

Diverse biomarkers and pathological alterations have been found in muscle of patients with Amyotrophic lateral sclerosis (ALS), but the relation between such alterations and dysfunction in energetic metabolism remains to be investigated. We established the metabolome of muscle and serum of ALS patie...

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Bibliographic Details
Main Authors: Débora Lanznaster, Clément Bruno, Jérôme Bourgeais, Patrick Emond, Ilyess Zemmoura, Antoine Lefèvre, Pascal Reynier, Sébastien Eymieux, Emmanuelle Blanchard, Patrick Vourc'h, Christian R. Andres, Salah Eddine Bakkouche, Olivier Herault, Luc Favard, Philippe Corcia, Hélène Blasco
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Biomedicines
Subjects:
Amyotrophic lateral sclerosis
metabolomics
mitochondria dysfunction
muscle
transcriptomics
Online Access:https://www.mdpi.com/2227-9059/10/6/1307

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