Proteomic Analysis Unveils Expressional Changes in Cytoskeleton- and Synaptic Plasticity-Associated Proteins in Rat Brain Six Months after Withdrawal from Morphine

Proteomic Analysis Unveils Expressional Changes in Cytoskeleton- and Synaptic Plasticity-Associated Proteins in Rat Brain Six Months after Withdrawal from Morphine

Drug withdrawal is associated with abstinence symptoms including deficits in cognitive functions that may persist even after prolonged discontinuation of drug intake. Cognitive deficits are, at least partially, caused by alterations in synaptic plasticity but the precise molecular mechanisms have no...

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Bibliographic Details
Main Authors: Zdenka Drastichova, Lucie Hejnova, Radka Moravcova, Jiri Novotny
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Life
Subjects:
morphine
withdrawal
brain
proteomics
synaptic plasticity
Online Access:https://www.mdpi.com/2075-1729/11/7/683

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