Antibody-mediated delivery of a viral MHC-I epitope into the cytosol of target tumor cells repurposes virus-specific CD8+ T cells for cancer immunotherapy

Antibody-mediated delivery of a viral MHC-I epitope into the cytosol of target tumor cells repurposes virus-specific CD8+ T cells for cancer immunotherapy

Abstract Background Redirecting pre-existing virus-specific cytotoxic CD8+ T lymphocytes (CTLs) to tumors by simulating a viral infection of the tumor cells has great potential for cancer immunotherapy. However, this strategy is limited by lack of amenable method for viral antigen delivery into the...

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Bibliographic Details
Main Authors:	Keunok Jung, Min-Jeong Son, Se-Young Lee, Jeong-Ah Kim, Deok-Han Ko, Sojung Yoo, Chul-Ho Kim, Yong-Sung Kim
Format:	Article
Language:	English
Published:	BMC 2022-04-01
Series:	Molecular Cancer
Subjects:	MHC-I epitope cytosolic delivery Cytosol-penetrating antibody Peptide–MHC-I complex Anti-viral cytotoxic T lymphocytes Cytomegalovirus therapeutic cancer vaccine
Online Access:	https://doi.org/10.1186/s12943-022-01574-0

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